7LMY
Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Transitional endoplasmic reticulum ATPase | polymer | 806 | 89493.9 | 6 | UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (Human) | TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP |
2 | E, F, A, B, C... | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 12 | Chemie (ATP) | |||
3 | E, F, A, B, C... | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine | non-polymer | 520.7 | 6 | Chemie (Y6Y) | |||
4 | E, F, A, B, C... | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) |
Sequence modifications
A, B, C, D, E, F: 1 - 806 (UniProt: P55072)
PDB | External Database | Details |
---|---|---|
Glu 232 | Ala 232 | engineered mutation |
Gln 578 | Glu 578 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 536963.1 | |
Non-Polymers* | Number of molecules | 30 |
Total formula weight | 9501.8 | |
All* | Total formula weight | 546464.9 |