6CX0
| Structure of AtTPC1 D376A | Descriptor: | (1S,3R)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid, CALCIUM ION, Two pore calcium channel protein 1 | Authors: | Kintzer, A.F, Stroud, R.M. | Deposit date: | 2018-04-02 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
8OUO
| Human TPC2 in Complex with Antagonist (S)-SG-094 | Descriptor: | (1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Chi, G, Pike, A.C.W, Maclean, E.M, Li, H, Mukhopadhyay, S.M.M, Bohstedt, T, Wang, D, McKinley, G, Fernandez-Cid, A, Duerr, K. | Deposit date: | 2023-04-24 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist. Structure, 2024
|
|
6V1Q
| Two-pore channel 3 | Descriptor: | SODIUM ION, Two pore channel 3 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2019-11-20 | Release date: | 2019-12-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Resting state structure of the hyperdepolarization activated two-pore channel 3. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7TDF
| AtTPC1 D454N with 1 mM EDTA state I | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-31 | Release date: | 2022-02-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7TBG
| AtTPC1 D454N with 1 mM Ca2+ | Descriptor: | CALCIUM ION, SODIUM ION, Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-22 | Release date: | 2022-02-02 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7TDD
| AtTPC1 D454N-EDTA state II | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-30 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7TDE
| AtTPC1 DDE mutant with 1 mM Ca2+ | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-31 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7VQ2
| Structure of Apo-hsTRPM2 channel TM domain | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
|
|
6YZ2
| Full length Open-form Sodium Channel NavMs F208L | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | Authors: | Sula, A, Sait, L.G, Hollingworth, D, Wallace, B.A. | Deposit date: | 2020-05-06 | Release date: | 2020-11-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Cannabidiol interactions with voltage-gated sodium channels. Elife, 9, 2020
|
|
9B8Y
| |
1BL8
| POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS | Descriptor: | POTASSIUM ION, PROTEIN (POTASSIUM CHANNEL PROTEIN) | Authors: | Doyle, D.A, Cabral, J.M, Pfuetzner, R.A, Kuo, A, Gulbis, J.M, Cohen, S.L, Chait, B.T, Mackinnon, R. | Deposit date: | 1998-07-23 | Release date: | 1998-07-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280, 1998
|
|
2W0F
| Potassium Channel KcsA-Fab Complex with Tetraoctylammonium | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, COBALT (II) ION, ... | Authors: | Lenaeus, M.J, Focia, P.J, Wagner, T, Gross, A. | Deposit date: | 2008-08-14 | Release date: | 2009-11-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site. Biochemistry, 53, 2014
|
|
1F6G
| POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD | Descriptor: | VOLTAGE-GATED POTASSIUM CHANNEL | Authors: | Cortes, D.M, Perozo, E. | Deposit date: | 2000-06-21 | Release date: | 2001-02-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J.Gen.Physiol., 117, 2001
|
|
6KEB
| |
5AN8
| Cryo-electron microscopy structure of rabbit TRPV2 ion channel | Descriptor: | TRPV2 | Authors: | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | Deposit date: | 2015-09-04 | Release date: | 2015-12-23 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-Electron Microscopy of the Trpv2 Ion Channel Nat.Struct.Mol.Biol., 23, 2016
|
|
6KZP
| calcium channel-ligand | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Yan, N. | Deposit date: | 2019-09-25 | Release date: | 2019-12-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of apo and antagonist-bound human Cav3.1. Nature, 576, 2019
|
|
3WKV
| Voltage-gated proton channel: VSOP/Hv1 chimeric channel | Descriptor: | Ion channel | Authors: | Takeshita, K, Sakata, S, Yamashita, E, Fujiwara, Y, Kawanabe, A, Kurokawa, T, Okochi, Y, Matsuda, M, Narita, H, Okamura, Y, Nakagawa, A. | Deposit date: | 2013-10-31 | Release date: | 2014-03-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.453 Å) | Cite: | X-ray crystal structure of voltage-gated proton channel. Nat.Struct.Mol.Biol., 21, 2014
|
|
1ORS
| X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab | Descriptor: | 33H1 Fab heavy chain, 33H1 Fab light chain, potassium channel | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2003-03-14 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of a voltage-dependent K+ channel Nature, 423, 2003
|
|
1ORQ
| X-ray structure of a voltage-dependent potassium channel in complex with an Fab | Descriptor: | 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ... | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2003-03-14 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray structure of a voltage-dependent K+ channel Nature, 423, 2003
|
|
5BZB
| NavMs voltage-gated sodium channel pore and C-terminal domain | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | Authors: | Naylor, C.E, Bagneris, C, Wallace, B.A. | Deposit date: | 2015-06-11 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis of ion permeability in a voltage-gated sodium channel. Embo J., 35, 2016
|
|
3ZJZ
| Open-form NavMS Sodium Channel Pore (with C-terminal Domain) | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, ION TRANSPORT PROTEIN, ... | Authors: | Bagneris, C, Naylor, C.E, Wallace, B.A. | Deposit date: | 2013-01-21 | Release date: | 2013-10-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Role of the C-Terminal Domain in the Structure and Function of Tetrameric Sodium Channels. Nat.Commun., 4, 2013
|
|
5KLG
| Structure of CavAb(W195Y) in complex with Br-dihydropyridine derivative UK-59811 | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | Authors: | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | Deposit date: | 2016-06-24 | Release date: | 2016-08-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs. Nature, 537, 2016
|
|
5MKF
| cryoEM Structure of Polycystin-2 in complex with calcium and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
|
|
2P7T
| Crystal Structure of KcsA mutant | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB-A, FAB-B, ... | Authors: | Cordero-Morales, J.F, Vishwanath, J, Lewis, A, Valeria, V.R, Cortes, D.M, Roux, B, Perozo, E. | Deposit date: | 2007-03-20 | Release date: | 2007-10-09 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of KcsA mutant To be Published
|
|
5MKE
| cryoEM Structure of Polycystin-2 in complex with cations and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
|
|