8OUO

Human TPC2 in Complex with Antagonist (S)-SG-094

Summary for 8OUO

Entry DOI	10.2210/pdb8ouo/pdb
EMDB information	17197
Descriptor	Two pore channel protein 2, di-heneicosanoyl phosphatidyl choline, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... (6 entities in total)
Functional Keywords	tpc2, two-pore channel, ion channel, inhibitor, homodimer, metal transport
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	180657.42
Authors	Chi, G.,Pike, A.C.W.,Maclean, E.M.,Li, H.,Mukhopadhyay, S.M.M.,Bohstedt, T.,Wang, D.,McKinley, G.,Fernandez-Cid, A.,Duerr, K. (deposition date: 2023-04-24, release date: 2024-06-12)
Primary citation	Chi, G.,Jaslan, D.,Kudrina, V.,Bock, J.,Li, H.,Pike, A.C.W.,Rautenberg, S.,Krogsaeter, E.,Bohstedt, T.,Wang, D.,McKinley, G.,Fernandez-Cid, A.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,Keller, M.,Bracher, F.,Grimm, C.,Durr, K.L. Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist. Structure, 2024 Cited by PubMed: 38815576 DOI: 10.1016/j.str.2024.05.005 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation