8OUO
Human TPC2 in Complex with Antagonist (S)-SG-094
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Two pore channel protein 2 | polymer | 752 | 85285.4 | 2 | UniProt (Q8NHX9) Pfam (PF00520) | Homo sapiens (human) | Two pore calcium channel protein 2 |
| 2 | C, K (A, B) | di-heneicosanoyl phosphatidyl choline | non-polymer | 875.3 | 2 | Chemie (PLD) | |||
| 3 | D, J, P (A, B) | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside | non-polymer | 1165.3 | 3 | Chemie (Q7G) | |||
| 4 | E (A) | (1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline | non-polymer | 451.6 | 1 | Chemie (W4E) | |||
| 5 | F, L (A, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE | non-polymer | 734.0 | 2 | Chemie (PCF) | |||
| 6 | G, H, I, M, N... (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 6 | Chemie (Y01) |
Sequence modifications
A, B: 1 - 752 (UniProt: Q8NHX9)
| PDB | External Database | Details |
|---|---|---|
| Ala 11 | Leu 11 | conflict |
| Ala 12 | Leu 12 | conflict |
| Pro 564 | Leu 564 | variant |
| Glu 734 | Gly 734 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 170570.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 10086.6 | |
| All* | Total formula weight | 180657.4 |
