PDB: 608 resultsInfo pagesStatus searchChemie searchBIRD

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4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 Descriptor: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... Authors: Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2013-12-18 Release date: 2014-04-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
5HF3	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma Descriptor: 14-3-3 protein sigma, modified Tau peptide Authors: Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. Deposit date: 2016-01-06 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
2V7D	14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide Descriptor: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT Authors: Takala, H, Ylanne, J. Deposit date: 2007-07-30 Release date: 2008-06-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood, 112, 2008
4QLI	A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2014-06-12 Release date: 2015-06-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation To be Published
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-15 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-17 Release date: 2014-02-19 Last modified: 2014-03-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4F7R	Crystal structure of 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein, SULFATE ION Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2012-05-16 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The Crystal Structure of Giardia duodenalis 14-3-3 in the Apo Form: When Protein Post-Translational Modifications Make the Difference. Plos One, 9, 2014
1A38	14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE Descriptor: 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) Authors: Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. Deposit date: 1998-01-28 Release date: 1999-03-02 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.35 Å) Cite: 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
3E6Y	Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2008-08-17 Release date: 2009-03-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
3EFZ	Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein Authors: Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) Deposit date: 2008-09-10 Release date: 2008-09-23 Last modified: 2012-02-22 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4FR3	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... Authors: Ottmann, C, Anders, C, Schumacher, B. Deposit date: 2012-06-26 Release date: 2013-05-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
4N7Y	Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-16 Release date: 2014-02-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase Authors: Ottmann, C, Molzan, M. Deposit date: 2012-06-11 Release date: 2012-09-05 Last modified: 2013-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
5ULO	Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, L-PROLINAMIDE, ... Authors: DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC) Deposit date: 2017-01-25 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide to be published
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
3IQJ	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer) Descriptor: 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-20 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-25 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
3CU8	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... Authors: Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. Deposit date: 2008-04-16 Release date: 2009-05-05 Last modified: 2017-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
5WFX	Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate Descriptor: 14-3-3 protein beta/alpha Authors: Hou, Z.Q. Deposit date: 2017-07-12 Release date: 2018-05-16 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.651 Å) Cite: Structural basis for the interaction of 14-3-3 beta withTricarboxylic Acid Cycle intermediate Malate To Be Published
5WFU	Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate Descriptor: 14-3-3 protein beta/alpha, D-MALATE Authors: Hou, Z.Q, Liu, X.Y. Deposit date: 2017-07-12 Release date: 2018-07-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate To Be Published
1A4O	14-3-3 PROTEIN ZETA ISOFORM Descriptor: 14-3-3 PROTEIN ZETA Authors: Liu, D, Bienkowska, J, Petosa, C, Collier, R.J, Fu, H, Liddington, R.C. Deposit date: 1998-02-01 Release date: 1999-03-02 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the zeta isoform of the 14-3-3 protein. Nature, 376, 1995
1A37	14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE Descriptor: 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM Authors: Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. Deposit date: 1998-01-28 Release date: 1999-03-02 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.6 Å) Cite: 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024

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