Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6SR6
DownloadVisualize
BU of 6sr6 by Molmil
Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ...
Authors:Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I.
Deposit date:2019-09-05
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.
Nat Commun, 11, 2020
5XI9
DownloadVisualize
BU of 5xi9 by Molmil
Solution structure for human HSP70 substrate binding domain
Descriptor: Heat shock 70 kDa protein 1A
Authors:Hoshikawa, M, Tochio, N, Tate, S.
Deposit date:2017-04-26
Release date:2018-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.
Molecules, 23, 2018
5XIR
DownloadVisualize
BU of 5xir by Molmil
Solution structure for human HSP70 substrate binding domain L542Y mutant
Descriptor: Heat shock 70 kDa protein 1A
Authors:Hoshikawa, M, Tochio, N, Tate, S.
Deposit date:2017-04-27
Release date:2018-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.
Molecules, 23, 2018
7F4Z
DownloadVisualize
BU of 7f4z by Molmil
X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1B, ...
Authors:Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M.
Deposit date:2021-06-21
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP.
Iucrj, 9, 2022
7F4X
DownloadVisualize
BU of 7f4x by Molmil
Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ...
Authors:Yokoyama, T, Ostermann, A, Schrader, T.E.
Deposit date:2021-06-21
Release date:2022-06-29
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION
Cite:Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP.
Iucrj, 9, 2022
7F50
DownloadVisualize
BU of 7f50 by Molmil
X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP
Descriptor: CHLORIDE ION, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ...
Authors:Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M.
Deposit date:2021-06-21
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP.
Iucrj, 9, 2022
7FGM
DownloadVisualize
BU of 7fgm by Molmil
The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Heat shock 70 kDa protein 1A, ...
Authors:Kim, E.E, ParK, J.K, Shin, S.C.
Deposit date:2021-07-27
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation
J Mol Cell Biol, 14, 2022
1QQN
DownloadVisualize
BU of 1qqn by Molmil
D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ...
Authors:Johnson, E.R, McKay, D.B.
Deposit date:1999-06-07
Release date:1999-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
Biochemistry, 38, 1999
1DKZ
DownloadVisualize
BU of 1dkz by Molmil
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS
Descriptor: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
6ASY
DownloadVisualize
BU of 6asy by Molmil
BiP-ATP2
Descriptor: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L.
Deposit date:2017-08-26
Release date:2017-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
Nat Commun, 8, 2017
1DKY
DownloadVisualize
BU of 1dky by Molmil
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS
Descriptor: DNAK, PEPTIDE SUBSTRATE
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
1DKX
DownloadVisualize
BU of 1dkx by Molmil
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS
Descriptor: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
3QFP
DownloadVisualize
BU of 3qfp by Molmil
Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain
Descriptor: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION
Authors:Yan, M, Li, J.Z, Sha, B.D.
Deposit date:2011-01-22
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.
Biochem.J., 438, 2011
6B1M
DownloadVisualize
BU of 6b1m by Molmil
Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant
Descriptor: GLYCEROL, Heat shock protein family A (Hsp70) member 8, MAGNESIUM ION, ...
Authors:O'Donnell, J.P.
Deposit date:2017-09-18
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.
Biochemistry, 57, 2018
6B1N
DownloadVisualize
BU of 6b1n by Molmil
Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ...
Authors:O'Donnell, J.P.
Deposit date:2017-09-18
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.
Biochemistry, 57, 2018
3QNJ
DownloadVisualize
BU of 3qnj by Molmil
Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin
Descriptor: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin
Authors:Zahn, M, Straeter, N.
Deposit date:2011-02-08
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex.
Chembiochem, 12, 2011
3QFU
DownloadVisualize
BU of 3qfu by Molmil
Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP
Descriptor: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Yan, M, Li, J.Z, Sha, B.D.
Deposit date:2011-01-22
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.
Biochem.J., 438, 2011
6B1I
DownloadVisualize
BU of 6b1i by Molmil
Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ...
Authors:O'Donnell, J.P.
Deposit date:2017-09-18
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.
Biochemistry, 57, 2018
1YUW
DownloadVisualize
BU of 1yuw by Molmil
crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Descriptor: Heat shock cognate 71 kDa protein
Authors:Jiang, J, Lafer, E.M, Prasad, K, Sousa, R.
Deposit date:2005-02-14
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of interdomain communication in the Hsc70 chaperone
Mol.Cell, 20, 2005
1QQM
DownloadVisualize
BU of 1qqm by Molmil
D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ...
Authors:Johnson, E.R, Mckay, D.B.
Deposit date:1999-06-07
Release date:1999-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
Biochemistry, 38, 1999
1QQO
DownloadVisualize
BU of 1qqo by Molmil
E175S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HYDROLASE (ACTING ON ACID ANHYDRIDES), ...
Authors:Johnson, E.R, McKay, D.B.
Deposit date:1999-06-07
Release date:1999-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
Biochemistry, 38, 1999
2BUP
DownloadVisualize
BU of 2bup by Molmil
T13G Mutant of the ATPASE fragment of Bovine HSC70
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Sousa, M.C, Mckay, D.B.
Deposit date:1998-09-08
Release date:1998-09-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change.
Biochemistry, 37, 1998
1S3X
DownloadVisualize
BU of 1s3x by Molmil
The crystal structure of the human Hsp70 ATPase domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ...
Authors:Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A.
Deposit date:2004-01-14
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
Structure, 5, 1997
2BPR
DownloadVisualize
BU of 2bpr by Molmil
NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES
Descriptor: DNAK
Authors:Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P.
Deposit date:1998-08-11
Release date:1999-03-02
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.
Biochemistry, 37, 1998
4R5K
DownloadVisualize
BU of 4r5k by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-B)
Descriptor: CALCIUM ION, Chaperone protein DnaK, SULFATE ION
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7469 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014

221371

数据于2024-06-19公开中

PDB statisticsPDBj update infoContact PDBjnumon