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3NZ1	Crystal Structure of Kemp Elimination Catalyst 1A53-2 Complexed with Transition State Analog 5-Nitro Benzotriazole Descriptor: 5-nitro-1H-benzotriazole, Indole-3-glycerol phosphate synthase, L(+)-TARTARIC ACID, ... Authors: Lee, T.M, Privett, H.K, Kaiser, J.T, Mayo, S.L. Deposit date: 2010-07-15 Release date: 2011-06-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Iterative approach to computational enzyme design. Proc.Natl.Acad.Sci.USA, 109, 2012
4ERN	Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1.80 A Descriptor: TFIIH basal transcription factor complex helicase XPB subunit Authors: Hilario, E, Li, Y, Fan, L. Deposit date: 2012-04-20 Release date: 2013-01-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE. Acta Crystallogr.,Sect.D, 69, 2013
4EYE	Crystal structure of a probable oxidoreductase from Mycobacterium abscessus solved by iodide ion SAD Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Probable oxidoreductase Authors: Edwards, T.E, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-05-01 Release date: 2012-05-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3OPF	Crystal structure of TTHA0988 in space group P212121 Descriptor: GLYCEROL, Putative uncharacterized protein TTHA0988, SULFATE ION Authors: Jacques, D.A, Kuramitsu, S, Yokoyama, S, Trewhella, J, Guss, J.M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2010-09-01 Release date: 2011-02-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase Acta Crystallogr.,Sect.D, 67, 2011
3OQ9	Structure of the FAS/FADD death domain assembly Descriptor: Protein FADD, Tumor necrosis factor receptor superfamily member 6 Authors: Kabaleeswaran, V, Wu, H. Deposit date: 2010-09-02 Release date: 2010-10-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (6.8 Å) Cite: The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat.Struct.Mol.Biol., 17, 2010
3OQI	Crystal structure of B. licheniformis CDPS yvmC-BLIC in complex with CHES Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Putative uncharacterized protein yvmC Authors: Bonnefond, L, Arai, T, Suzuki, T, Ishitani, R, Nureki, O. Deposit date: 2010-09-03 Release date: 2011-02-23 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (1.701 Å) Cite: Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog. Proc.Natl.Acad.Sci.USA, 108, 2011
3P3E	Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex Descriptor: N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, NITRATE ION, SODIUM ION, ... Authors: Lee, C.-J, Zhou, P. Deposit date: 2010-10-04 Release date: 2011-01-05 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
3OVJ	Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G Descriptor: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, KLVFFA hexapeptide segment from Amyloid beta Authors: Landau, M, Eisenberg, D. Deposit date: 2010-09-16 Release date: 2011-07-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Towards a pharmacophore for amyloid. Plos Biol., 9, 2011
3P3G	Crystal Structure of the Escherichia coli LpxC/LPC-009 complex Descriptor: 4-ethynyl-N-[(1S,2R)-2-hydroxy-1-(oxocarbamoyl)propyl]benzamide, DIMETHYL SULFOXIDE, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ... Authors: Lee, C.-J, Zhou, P. Deposit date: 2010-10-04 Release date: 2011-01-05 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
3OMU	Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative Descriptor: 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, Heat shock protein 83 Authors: Wernimont, A.K, Hutchinson, A, Sullivan, H, Weadge, J, Cossar, D, Li, Y, Kozieradzki, I, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Wyatt, P.G, Fairlamb, A.H, MacKenzie, C, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2010-08-27 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7, 2013
3OZ6	Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960 Descriptor: GLYCEROL, Mitogen-activated protein kinase 1, serine/threonine protein kinase Authors: Wernimont, A.K, Lew, J, Lin, Y.H, Sullivan, H, Hassanali, A, Kozieradzki, I, Cossar, D, Arrowsmith, C.H, Bochkarev, A, Bountra, C, Edwards, A.M, Weigelt, J, Hui, R, Neculai, A.M, Hutchinson, A, Structural Genomics Consortium (SGC) Deposit date: 2010-09-24 Release date: 2010-12-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960 To be Published
3OVL	Structure of an amyloid forming peptide VQIVYK from the TAU protein in complex with orange G Descriptor: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, ACETIC ACID, Microtubule-associated protein, ... Authors: Landau, M, Eisenberg, D. Deposit date: 2010-09-16 Release date: 2011-07-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Towards a pharmacophore for amyloid. Plos Biol., 9, 2011
3NFW	Crystal structure of nitrilotriacetate monooxygenase component B (A0R521 homolog) from Mycobacterium thermoresistibile Descriptor: Flavin reductase-like, FMN-binding protein, GLYCEROL Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-06-10 Release date: 2010-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. Acta Crystallogr.,Sect.F, 67, 2011
3OWF	Crystal structure of Staphylococcal nuclease variant Delta+PHS V66R at cryogenic temperature Descriptor: CALCIUM ION, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... Authors: Schlessman, J.L, Khangulov, V, Heroux, A, Garcia-Moreno E, B. Deposit date: 2010-09-17 Release date: 2010-10-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Domain swapping promoted by a single mutation that introduces an ionizable group into the hydrophobic core of a protein To be Published
3P1E	Crystal structure of the bromodomain of human CREBBP in complex with dimethyl sulfoxide (DMSO) Descriptor: CREB-binding protein, DIMETHYL SULFOXIDE, POTASSIUM ION, ... Authors: Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2010-09-30 Release date: 2010-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the bromodomain of human CREBBP in complex with dimethyl sulfoxide (DMSO) To be Published
3P5M	Crystal structure of an enoyl-CoA hydratase/isomerase from Mycobacterium avium Descriptor: 1,2-ETHANEDIOL, Enoyl-CoA hydratase/isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-10-08 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
7K5I	SARS-COV-2 nsp1 in complex with human 40S ribosome Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... Authors: Wang, L, Shi, M, Wu, H. Deposit date: 2020-09-16 Release date: 2020-10-14 Last modified: 2021-03-17 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. Biorxiv, 2020
4EVO	Crystal structure of Staphylococcal nuclease variant NVIAGA/E122G at cryogenic temperature Descriptor: PHOSPHATE ION, Thermonuclease Authors: Doctrow, B.M, Schlessman, J.L, Garcia-Moreno E, B, Heroux, A. Deposit date: 2012-04-26 Release date: 2012-05-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Local flexibility as a determinant of pKa values of surface ionizable groups in proteins To be Published
3P4I	Crystal structure of acetate kinase from Mycobacterium avium Descriptor: 1,2-ETHANEDIOL, Acetate kinase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-10-06 Release date: 2010-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4EWW	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-28 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EX0	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-29 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
3PDR	Crystal structure of manganese bound M-box RNA Descriptor: M-box Riboswitch RNA, MANGANESE (II) ION, POTASSIUM ION Authors: Ramesh, A, Winkler, W.C. Deposit date: 2010-10-23 Release date: 2011-02-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.853 Å) Cite: Insights into Metalloregulation by M-box Riboswitch RNAs via Structural Analysis of Manganese-Bound Complexes. J.Mol.Biol., 407, 2011
4EXT	Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta Descriptor: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit Authors: Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S. Deposit date: 2012-05-01 Release date: 2013-05-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain To be Published
4EYN	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-01 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.532 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4F0O	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-04 Release date: 2013-05-08 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (1.672 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013

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