PDB: 4939 resultsInfo pagesStatus searchChemie searchBIRD

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6SG4	Structure of CDK2/cyclin A M246Q, S247EN Descriptor: Cyclin-A2, Cyclin-dependent kinase 2 Authors: Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. Deposit date: 2019-08-02 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
3C4W	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
6T41	CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine Descriptor: 1,2-ETHANEDIOL, Cyclin-C, Cyclin-dependent kinase 8, ... Authors: Schneider, E.V, Maskos, K, Huber, R, Kuhn, C.-D. Deposit date: 2019-10-11 Release date: 2020-01-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.45 Å) Cite: A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc.Natl.Acad.Sci.USA, 117, 2020
3C4Z	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
6Z3U	Structure of the CAK complex form Chaetomium thermophilum Descriptor: CHLORIDE ION, CYCLIN domain-containing protein, Protein kinase domain-containing protein, ... Authors: Peissert, S, Kuper, J, Kisker, C. Deposit date: 2020-05-22 Release date: 2020-12-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for CDK7 activation by MAT1 and Cyclin H. Proc.Natl.Acad.Sci.USA, 117, 2020
6TD3	Structure of DDB1 bound to CR8-engaged CDK12-cyclinK Descriptor: (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Bunker, R.D, Petzold, G, Kozicka, Z, Thoma, N.H. Deposit date: 2019-11-07 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.46 Å) Cite: The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585, 2020
6RSU	TBK1 in complex with Inhibitor compound 35 Descriptor: 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1 Authors: Panne, D, Hillig, R.C, Rengachari, S. Deposit date: 2019-05-22 Release date: 2020-04-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
6TM5	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Alfieri, C, Barford, D. Deposit date: 2019-12-03 Release date: 2020-02-19 Last modified: 2020-06-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
3C50	Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3BLH	Crystal Structure of Human CDK9/cyclinT1 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 Authors: Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. Deposit date: 2007-12-11 Release date: 2008-07-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
3BLR	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol Descriptor: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... Authors: Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. Deposit date: 2007-12-11 Release date: 2008-07-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
3C4Y	Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A Descriptor: Rhodopsin kinase Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (7.509 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3A62	Crystal structure of phosphorylated p70S6K1 Descriptor: MANGANESE (II) ION, Ribosomal protein S6 kinase beta-1, STAUROSPORINE Authors: Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. Deposit date: 2009-08-18 Release date: 2009-10-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
3A61	Crystal structure of unphosphorylated p70S6K1 (Form II) Descriptor: Ribosomal protein S6 kinase beta-1, STAUROSPORINE Authors: Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. Deposit date: 2009-08-18 Release date: 2009-10-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.43 Å) Cite: Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
3C51	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A Descriptor: ADENOSINE-5'-DIPHOSPHATE, BROMIDE ION, MAGNESIUM ION, ... Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.55 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
3C4X	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... Authors: Singh, P, Tesmer, J.J.G. Deposit date: 2008-01-30 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem., 283, 2008
4JBV	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268 Descriptor: 1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Merritt, E.A, Larson, E.T. Deposit date: 2013-02-20 Release date: 2014-03-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014
2C5O	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 Authors: Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2005-10-30 Release date: 2006-03-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2BKZ	STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611 Descriptor: 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: DAlessio, R, Bargiottia, A, Metz, S, Brasca, M.G, Cameron, A, Ermoli, A, Marsiglio, A, Polucci, P, Roletto, F, Tibolla, M, Vazquez, M.L, Vulpetti, A, Pevarello, P. Deposit date: 2005-02-23 Release date: 2006-03-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Benzodipyrazoles: A New Class of Potent Cdk2 Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
4L44	Crystal structures of human p70S6K1-T389A (form II) Descriptor: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... Authors: Wang, J, Zhong, C, Ding, J. Deposit date: 2013-06-07 Release date: 2013-07-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L42	Crystal structures of human p70S6K1-PIF Descriptor: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... Authors: Wang, J, Zhong, C, Ding, J. Deposit date: 2013-06-07 Release date: 2013-07-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
2BPM	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529 Descriptor: (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: Cameron, A, Fogliatto, G, Pevarello, P, Brasca, M.G, Orsini, P, Traquandi, G, Longo, A, Nesi, M, Orzi, F, Piutti, C, Sansonna, P, Varasi, M, Vulpetti, A, Roletto, F, Alzani, R, Ciomei, M, Albanese, C, Pastori, W, Marsiglio, A, Pesenti, E, Fiorentini, F, Bischoff, J.R, Mercurio, C. Deposit date: 2005-04-21 Release date: 2005-12-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: 3-Aminopyrazole Inhibitors of Cdk2-Cyclin a as Antitumor Agents. 2. Lead Optimization J.Med.Chem., 48, 2005
4LQQ	Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B Descriptor: CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 Authors: Gogl, G, Remenyi, A. Deposit date: 2013-07-19 Release date: 2014-07-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
4MD8	Crystal Structure of full-length symmetric CK2 holoenzyme with mutated alpha subunit (F121E) Descriptor: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION Authors: Lolli, G, Ranchio, A, Battistutta, R. Deposit date: 2013-08-22 Release date: 2013-11-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Active Form of the Protein Kinase CK2 alpha 2 beta 2 Holoenzyme Is a Strong Complex with Symmetric Architecture. Acs Chem.Biol., 9, 2014
2C5V	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... Authors: Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2005-11-02 Release date: 2006-03-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

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