6TD3

Structure of DDB1 bound to CR8-engaged CDK12-cyclinK

Summary for 6TD3

• Entry DOI: 10.2210/pdb6td3/pdb
• Descriptor: DNA damage-binding protein 1, Cyclin-dependent kinase 12, Cyclin-K, ... (4 entities in total)
• Functional Keywords: ubiquitin ligase kinase cyclin cdk, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 497852.31

Authors

Bunker, R.D.,Petzold, G.,Kozicka, Z.,Thoma, N.H. (deposition date: 2019-11-07, release date: 2020-06-17, Last modification date: 2024-01-24)

• Primary citation: Slabicki, M.,Kozicka, Z.,Petzold, G.,Li, Y.D.,Manojkumar, M.,Bunker, R.D.,Donovan, K.A.,Sievers, Q.L.,Koeppel, J.,Suchyta, D.,Sperling, A.S.,Fink, E.C.,Gasser, J.A.,Wang, L.R.,Corsello, S.M.,Sellar, R.S.,Jan, M.,Gillingham, D.,Scholl, C.,Frohling, S.,Golub, T.R.,Fischer, E.S.,Thoma, N.H.,Ebert, B.L.; The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.; Nature, 585:293-297, 2020; PubMed: 32494016; DOI: 10.1038/s41586-020-2374-x

Experimental method

X-RAY DIFFRACTION (3.46 Å)