6T41

CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine

Summary for 6T41

Entry DOI	10.2210/pdb6t41/pdb
Descriptor	Cyclin-dependent kinase 8, Cyclin-C, ~{N}-[(4-chlorophenyl)methyl]quinazolin-4-amine, ... (6 entities in total)
Functional Keywords	cyclin-dependent kinase, inhibitor complex, mediator kinase module, mediator, transcriptional kinase, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	81361.98
Authors	Schneider, E.V.,Maskos, K.,Huber, R.,Kuhn, C.-D. (deposition date: 2019-10-11, release date: 2020-01-01, Last modification date: 2024-01-24)
Primary citation	Klatt, F.,Leitner, A.,Kim, I.V.,Ho-Xuan, H.,Schneider, E.V.,Langhammer, F.,Weinmann, R.,Muller, M.R.,Huber, R.,Meister, G.,Kuhn, C.D. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc.Natl.Acad.Sci.USA, 117:2894-2905, 2020 Cited by PubMed: 31988137 DOI: 10.1073/pnas.1917635117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation