6T41
CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 407 | 47205.0 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 286 | 33595.0 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | C (A) | ~{N}-[(4-chlorophenyl)methyl]quinazolin-4-amine | non-polymer | 269.7 | 1 | Chemie (MFE) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E, F, G, H, I (A, B) | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 1 - 404 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80800.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 561.9 | |
| All* | Total formula weight | 81362.0 |
