6T41

CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	407	47205.0	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	286	33595.0	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	~{N}-[(4-chlorophenyl)methyl]quinazolin-4-amine	non-polymer		269.7	1	Chemie (MFE)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	A, B	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
6		water	water		18.0	144	Chemie (HOH)

Sequence modifications

A: 1 - 404 (UniProt: P49336)

PDB	External Database	Details
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag

B: 1 - 283 (UniProt: P24863)

PDB	External Database	Details
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80800.1
Non-Polymers*	Number of molecules	7
	Total formula weight	561.9
All*	Total formula weight	81362.0

*Water molecules are not included.