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5ZJ1
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BU of 5zj1 by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative CYT-14
Descriptor: 1,2-ETHANEDIOL, Metallo-beta-lactamase type 2, ZINC ION, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-18
Release date:2019-03-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
5ZGQ
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BU of 5zgq by Molmil
Crystal structure of NDM-1 at pH7.5 (Tris-HCl, (NH4)2SO4) in complex with hydrolyzed ampicillin
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGZ
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BU of 5zgz by Molmil
Crystal structure of NDM-1 at pH7.5 (Imidazole) with 1 molecule per asymmetric unit
Descriptor: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZR8
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BU of 5zr8 by Molmil
Crystal Structure Of NDM-1 Metallo-beta-lactamase
Descriptor: Beta-lactamase, SULFATE ION, ZINC ION
Authors:Wachino, J.
Deposit date:2018-04-23
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure Of NDM-1 Metallo-beta-lactamase
To Be Published
6BM9
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BU of 6bm9 by Molmil
Directed evolutionary changes in MBL super family - VIM-2 Round 10
Descriptor: GLYCEROL, Metallo-beta-lactamase, ZINC ION
Authors:Hong, N.-S, Jackson, C.J, Carr, P.D.
Deposit date:2017-11-13
Release date:2018-11-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.
Elife, 8, 2019
5ZGY
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BU of 5zgy by Molmil
Crystal structure of NDM-1 at pH7.5 (Bis-Tris) with 1 molecule per asymmetric unit
Descriptor: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZJ8
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BU of 5zj8 by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative CY32
Descriptor: (2S)-2,3-disulfanylpropan-1-ol, 1,2-ETHANEDIOL, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-19
Release date:2019-03-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of NDM-1
to be published
5ZH1
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BU of 5zh1 by Molmil
Crystal structure of NDM-1 at pH7.5 (Imidazole) with 2 molecules per asymmetric unit
Descriptor: HYDROXIDE ION, IMIDAZOLE, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
6AUF
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BU of 6auf by Molmil
Crystal structure of Metalo beta Lactamases MIM-1 from Novosphingobium pentaromativorans
Descriptor: Beta-lactamase-like protein, CITRIC ACID, ZINC ION
Authors:Selleck, C.
Deposit date:2017-08-31
Release date:2018-09-12
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Crystal structure of Metalo beta Lactamases MIM-1 from Novosphingobium pentaromativorans
To Be Published
5ZGP
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BU of 5zgp by Molmil
Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGF
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BU of 5zgf by Molmil
Crystal structure of NDM-1 Q123G mutant
Descriptor: HYDROXIDE ION, Metallo-beta-lactamase type 2, ZINC ION
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGI
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BU of 5zgi by Molmil
Crystal structure of NDM-1 at pH6.5 (Succinate) with 1 molecule per asymmetric unit
Descriptor: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-09
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGX
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BU of 5zgx by Molmil
Crystal structure of NDM-1 at pH7.5 (Succinate) with 1 molecule per asymmetric unit
Descriptor: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
Authors:Zhang, H, Hao, Q.
Deposit date:2018-03-10
Release date:2018-08-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
6C89
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BU of 6c89 by Molmil
NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
Authors:Palzkill, T, Sun, Z, Sankaran, B.
Deposit date:2018-01-24
Release date:2018-12-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75006151 Å)
Cite:Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics.
Nat Commun, 9, 2018
6C6I
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BU of 6c6i by Molmil
Crystal structure of a chimeric NDM-1 metallo-beta-lactamase harboring the IMP-1 L3 loop
Descriptor: Metallo-beta-lactamase type 2 chimera, ZINC ION
Authors:Otero, L, Giannini, E, Klinke, S, Palacios, A, Mojica, M, Bonomo, R, Llarrull, L, Vila, A.
Deposit date:2018-01-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019
7U2R
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BU of 7u2r by Molmil
Structure of Paenibacillus sp. J14 Apyc1
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2022-06-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7U2S
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BU of 7u2s by Molmil
Structure of Paenibacillus xerothermodurans Apyc1 in the apo state
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7TZ9
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BU of 7tz9 by Molmil
Structure of PQS Response Protein PqsE(E182W) Variant
Descriptor: FE (III) ION, Quinolone signal response protein
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-02-15
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7TZA
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BU of 7tza by Molmil
Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, N-{4-[(2,2-dimethylpropyl)carbamamido]phenyl}-1H-indazole-7-carboxamide, ...
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-02-15
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7U6G
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BU of 7u6g by Molmil
Structure of PQS Response Protein PqsE(E182W,E280A) Variant
Descriptor: FE (III) ION, Quinolone signal response protein
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-03-04
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
4ZO2
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BU of 4zo2 by Molmil
AidC, a Dizinc Quorum-Quenching Lactonase
Descriptor: Acylhomoserine lactonase, ZINC ION
Authors:Mascarenhas, R, Thomas, P.W, Wu, C.-X, Nocek, B.P, Hoang, Q, Fast, W, Liu, D.
Deposit date:2015-05-05
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity.
Biochemistry, 54, 2015
4ZO3
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BU of 4zo3 by Molmil
AidC, a Dizinc Quorum-Quenching Lactonase, in complex with a product N-hexnoyl-L-homoserine
Descriptor: Acylhomoserine lactonase, N-hexanoyl-L-homoserine, ZINC ION
Authors:Mascarenhas, R, Thomas, P.W, Wu, C.-X, Nocek, B.P, Hoang, Q, Fast, W, Liu, D.
Deposit date:2015-05-05
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity.
Biochemistry, 54, 2015
7UHM
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BU of 7uhm by Molmil
Time-Resolved Structure of Metallo Beta-Lactamase L1 in a Complex with Cleaved Moxalactam (150 ms Snapshot)
Descriptor: (2R)-2-[(R)-carboxy{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}methoxymethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid, Putative metallo-beta-lactamase l1 (Beta-lactamase type ii) (Ec 3.5.2.6) (Penicillinase), ZINC ION
Authors:Wilamowski, M, Kim, Y, Sherrell, D.A, Lavens, A, Henning, R, Maltseva, N, Endres, M, Babnigg, G, Srajer, V, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2022-03-27
Release date:2022-06-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.
Nat Commun, 13, 2022
7UHO
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BU of 7uho by Molmil
Time-Resolved Structure of Metallo Beta-Lactamase L1 in a Complex with Cleaved Moxalactam (500 ms Snapshot)
Descriptor: (2R)-2-[(R)-carboxy{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}methoxymethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid, Putative metallo-beta-lactamase l1 (Beta-lactamase type ii) (Ec 3.5.2.6) (Penicillinase), ZINC ION
Authors:Wilamowski, M, Kim, Y, Sherrell, D.A, Lavens, A, Henning, R, Maltseva, N, Endres, M, Babnigg, G, Srajer, V, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2022-03-27
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.
Nat Commun, 13, 2022
4ZEJ
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BU of 4zej by Molmil
Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime
Descriptor: CHLORIDE ION, Metallo-beta-lactamase, ZINC ION
Authors:Booth, M.P.S, Kosmopoulou, M, Spencer, J.
Deposit date:2015-04-20
Release date:2015-05-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal Stricture of DIM-1 Metallo-beta-Lactamase
To Be Published

221371

数据于2024-06-19公开中

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