5A5Z

Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria

Summary for 5A5Z

• Entry DOI: 10.2210/pdb5a5z/pdb
• Descriptor: BETA-LACTAMASE NDM-1, ZINC ION, TIOPRONIN, ... (4 entities in total)
• Functional Keywords: hydrolase, metallo-beta-lactamase, ndm-1, new delhi metallo- beta-lactamase 1, tiopronin
• Biological source: KLEBSIELLA PNEUMONIAE
• Total number of polymer chains: 2
• Total formula weight: 54256.37

Authors

Klingler, F.M.,Wichelhaus, T.A.,Frank, D.,Cuesta-Bernal, J.,El-Delik, J.,Mueller, H.F.,Sjuts, H.,Goettig, S.,Koenigs, A.,Pogoryelov, D.,Proschak, E. (deposition date: 2015-06-23, release date: 2015-07-08, Last modification date: 2024-01-10)

• Primary citation: Klingler, F.M.,Wichelhaus, T.A.,Frank, D.,Cuesta-Bernal, J.,El-Delik, J.,Muller, H.F.,Sjuts, H.,Gottig, S.,Koenigs, A.,Pos, K.M.,Pogoryelov, D.,Proschak, E.; Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.; J. Med. Chem., 58:3626-3630, 2015; PubMed: 25815530; DOI: 10.1021/jm501844d

Experimental method

X-RAY DIFFRACTION (2.6 Å)