5A5Z
Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | BETA-LACTAMASE NDM-1 | polymer | 251 | 26834.2 | 2 | UniProt (C7C422) Pfam (PF00753) | KLEBSIELLA PNEUMONIAE | NDM-1, METALLO-BETA-LACTAMASE NDM-1 |
| 2 | C, D, F, G (A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, H (A, C) | TIOPRONIN | non-polymer | 163.2 | 2 | Chemie (WJZ) | |||
| 4 | I, J (A, C) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, C: 29 - 270 (UniProt: C7C422)
| PDB | External Database | Details |
|---|---|---|
| Met 28 | - | expression tag |
| Leu 271 | - | expression tag |
| Glu 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53668.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 588.0 | |
| All* | Total formula weight | 54256.4 |
