4D1U

A D120A mutant of VIM-7 from Pseudomonas aeruginosa

Summary for 4D1U

• Entry DOI: 10.2210/pdb4d1u/pdb
• Related: 4D1T 4D1V 4D1W
• Descriptor: METALLO-B-LACTAMASE, ZINC ION (3 entities in total)
• Functional Keywords: hydrolase, residue determinants, ligand interaction
• Biological source: PSEUDOMONAS AERUGINOSA
• Total number of polymer chains: 1
• Total formula weight: 28163.24

Authors

Leiros, H.-K.S.,Skagseth, S.,Edvardsen, K.S.W.,Lorentzen, M.S.,Bjerga, G.E.K.,Leiros, I.,Samuelsen, O. (deposition date: 2014-05-05, release date: 2014-06-25, Last modification date: 2023-12-20)

• Primary citation: Leiros, H.-K.S.,Skagseth, S.,Edvardsen, K.S.W.,Lorentzen, M.S.,Bjerga, G.E.K.,Leiros, I.,Samuelsen, O.; His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency in the Metallo-Beta-Lactamase Vim-7.; Antimicrob.Agents Chemother., 58:4826-, 2014; PubMed: 24913158; DOI: 10.1128/AAC.02735-13

Experimental method

X-RAY DIFFRACTION (1.8 Å)