7UHO

Time-Resolved Structure of Metallo Beta-Lactamase L1 in a Complex with Cleaved Moxalactam (500 ms Snapshot)

Summary for 7UHO

• Entry DOI: 10.2210/pdb7uho/pdb
• Related: 7L91
• Descriptor: Putative metallo-beta-lactamase l1 (Beta-lactamase type ii) (Ec 3.5.2.6) (Penicillinase), ZINC ION, (2R)-2-[(R)-carboxy{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}methoxymethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: metallo beta lactamase, moxalactam, serial crystallography, structural genomics, center for structural genomics of infectious diseases, hydrolase, csgid
• Biological source: Stenotrophomonas maltophilia K279a
• Total number of polymer chains: 1
• Total formula weight: 29913.24

Authors

Wilamowski, M.,Kim, Y.,Sherrell, D.A.,Lavens, A.,Henning, R.,Maltseva, N.,Endres, M.,Babnigg, G.,Srajer, V.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2022-03-27, release date: 2022-07-13, Last modification date: 2023-10-25)

• Primary citation: Wilamowski, M.,Sherrell, D.A.,Kim, Y.,Lavens, A.,Henning, R.W.,Lazarski, K.,Shigemoto, A.,Endres, M.,Maltseva, N.,Babnigg, G.,Burdette, S.C.,Srajer, V.,Joachimiak, A.; Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.; Nat Commun, 13:7379-7379, 2022; PubMed: 36450742; DOI: 10.1038/s41467-022-35029-3

Experimental method

X-RAY DIFFRACTION (2.2 Å)