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2M7B
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BU of 2m7b by Molmil
ORF PP_3909 from Pseudomonas putida KT2440 encoding a protein similar to bacteriophage lambda ea8.5
Descriptor: ZINC ION, uncharacterized protein
Authors:Donaldson, L.W.F.
Deposit date:2013-04-18
Release date:2013-06-12
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The Solution Structures of Two Prophage Homologues of the Bacteriophage lambda Ea8.5 Protein Reveal a Newly Discovered Hybrid Homeodomain/Zinc-Finger Fold.
Biochemistry, 52, 2013
2P59
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BU of 2p59 by Molmil
Crystal Structure of Hepatitis C Virus NS3.4A protease
Descriptor: (2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE, NS3, peptide
Authors:Perni, R.B, Wei, Y.
Deposit date:2007-03-14
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Bioorg.Med.Chem.Lett., 17, 2007
1EID
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BU of 1eid by Molmil
CRYSTAL STRUCTURE OF F120G MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A
Descriptor: RIBONUCLEASE A
Authors:Chatani, E, Hayashi, R, Moriyama, H, Ueki, T.
Deposit date:2000-02-25
Release date:2002-02-13
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 A resolution.
Protein Sci., 11, 2002
1EIC
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BU of 1eic by Molmil
CRYSTAL STRUCTURE OF F120A MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A
Descriptor: RIBONUCLEASE A
Authors:Chatani, E, Hayashi, R, Moriyama, H, Ueki, T.
Deposit date:2000-02-25
Release date:2002-02-13
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 A resolution.
Protein Sci., 11, 2002
7SHH
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BU of 7shh by Molmil
Bacterial cereblon homologue in complex with (R)-3-(4-methoxyphenyl)piperidine-2,6-dione
Descriptor: (3R)-3-(4-methoxyphenyl)piperidine-2,6-dione, Cereblon isoform 4, ZINC ION
Authors:Nithianantham, S, Fischer, M.
Deposit date:2021-10-08
Release date:2022-04-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
Acs Med.Chem.Lett., 13, 2022
7B5K
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BU of 7b5k by Molmil
E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.
Descriptor: 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ...
Authors:Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z.
Deposit date:2020-12-03
Release date:2021-05-26
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities
Nat Commun, 2021
5GSQ
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BU of 5gsq by Molmil
Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, C.-L, Hsu, J.-C, Lin, C.-W, Wu, C.-Y, Wong, C.-H, Ma, C.
Deposit date:2016-08-17
Release date:2017-06-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity
ACS Chem. Biol., 12, 2017
5IDZ
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BU of 5idz by Molmil
Structure of Human Enolase 2 in complex with (S)-(1-hydroxy-2-oxopiperidin-3-yl)phosphonate
Descriptor: Gamma-enolase, MAGNESIUM ION, TRIETHYLENE GLYCOL, ...
Authors:Leonard, P.G, Muller, F.L.
Deposit date:2016-02-24
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Pomhex, a cell-permeable Enolase inhibitor for Collateral Lethality targeting of ENO1-deleted Glioblastoma
To Be Published
5JPL
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BU of 5jpl by Molmil
LP2006, a handcuff-topology lasso peptide antibiotic
Descriptor: Uncharacterized protein
Authors:Tietz, J.I, Schwalen, C.J, Blair, P.M, Zakai, U.I, Mitchell, D.A.
Deposit date:2016-05-03
Release date:2017-03-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A new genome-mining tool redefines the lasso peptide biosynthetic landscape.
Nat. Chem. Biol., 13, 2017
5H5O
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BU of 5h5o by Molmil
A cyclic-GMP-dependent signalling pathway regulates bacterial phytopathogenesis
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Diguanylate cyclase
Authors:Chin, K.H, Chou, S.-H.
Deposit date:2016-11-08
Release date:2017-05-24
Method:X-RAY DIFFRACTION (2.122 Å)
Cite:A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis
EMBO J., 32, 2013
5EU9
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BU of 5eu9 by Molmil
Structure of Human Enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid
Descriptor: ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid, Gamma-enolase, MAGNESIUM ION, ...
Authors:Leonard, P.G, Muller, F.L.
Deposit date:2015-11-18
Release date:2016-11-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:SF2312, a natural phosphonate inhibitor of Enolase
To be Published
2HRR
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BU of 2hrr by Molmil
Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, N-acetyl-alpha-neuraminic acid, ...
Authors:Fleming, C.D, Redinbo, M.R.
Deposit date:2006-07-20
Release date:2007-05-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
2HRQ
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BU of 2hrq by Molmil
Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD)
Descriptor: (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, ...
Authors:Fleming, C.D, Redinbo, M.R.
Deposit date:2006-07-20
Release date:2007-05-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
1EIE
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BU of 1eie by Molmil
CRYSTAL STRUCTURE OF F120W MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A
Descriptor: RIBONUCLEASE A
Authors:Chatani, E, Hayashi, R, Moriyama, H, Ueki, T.
Deposit date:2000-02-25
Release date:2002-02-13
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 A resolution.
Protein Sci., 11, 2002
6CUC
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BU of 6cuc by Molmil
Solution structure of double knot toxin (DkTx)
Descriptor: Tau-theraphotoxin-Hs1a
Authors:Ramanujam, V, Mobli, M.
Deposit date:2018-03-25
Release date:2019-03-27
Last modified:2024-04-24
Method:SOLUTION NMR
Cite:Structural Basis of the Bivalency of the TRPV1 Agonist DkTx.
Angew.Chem.Int.Ed.Engl., 63, 2024
3CWX
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BU of 3cwx by Molmil
Crystal structure of cagd from helicobacter pylori pathogenicity island
Descriptor: protein CagD
Authors:Cendron, L, Zanotti, G, Angelini, A, Barison, N, Couturier, M, Stein, M.
Deposit date:2008-04-23
Release date:2008-12-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
J.Mol.Biol., 386, 2009
1FS3
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BU of 1fs3 by Molmil
CRYSTAL STRUCTURE OF WILD-TYPE BOVINE PANCREATIC RIBONUCLEASE A
Descriptor: Ribonuclease A
Authors:Chatani, E, Hayashi, R, Moriyama, H, Ueki, T.
Deposit date:2000-09-08
Release date:2002-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 A resolution.
Protein Sci., 11, 2002
4TX3
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BU of 4tx3 by Molmil
Complex of the X-domain and OxyB from Teicoplanin Biosynthesis
Descriptor: 1,2-ETHANEDIOL, OxyB protein, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Peschke, M, Haslinger, K, Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-02-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.
Nature, 521, 2015
4I5C
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BU of 4i5c by Molmil
The Jak1 kinase domain in complex with inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6H)-yl)piperidin-1-yl]propanenitrile, Tyrosine-protein kinase JAK1
Authors:Fong, R, Lupardus, P.J.
Deposit date:2012-11-28
Release date:2013-05-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg.Med.Chem.Lett., 23, 2013
3CWY
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BU of 3cwy by Molmil
Structure of CagD from H. pylori pathogenicity island crystallized in the presence of Cu(II) ions
Descriptor: COPPER (II) ION, protein CagD
Authors:Cendron, L, Zanotti, G, Angelini, A, Barison, N, Couturier, M, Stein, M.
Deposit date:2008-04-23
Release date:2008-12-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
J.Mol.Biol., 386, 2009
5NV3
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BU of 5nv3 by Molmil
Structure of Rubisco from Rhodobacter sphaeroides in complex with CABP
Descriptor: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase large chain, ...
Authors:Bracher, A, Milicic, G, Ciniawsky, S, Wendler, P, Hayer-Hartl, M, Hartl, F.U.
Deposit date:2017-05-03
Release date:2017-07-26
Last modified:2017-09-20
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Mechanism of Enzyme Repair by the AAA(+) Chaperone Rubisco Activase.
Mol. Cell, 67, 2017
4DXD
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BU of 4dxd by Molmil
Staphylococcal Aureus FtsZ in complex with 723
Descriptor: 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE
Authors:Lu, J, Soisson, S.M.
Deposit date:2012-02-27
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Restoring methicillin-resistant Staphylococcus aureus susceptibility to beta-lactam antibiotics.
Sci Transl Med, 4, 2012
4E5W
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BU of 4e5w by Molmil
JAK1 kinase (JH1 domain) in complex with compound 26
Descriptor: DI(HYDROXYETHYL)ETHER, Tyrosine-protein kinase JAK1, [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl][(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methanone
Authors:Murray, J.M.
Deposit date:2012-03-14
Release date:2012-05-30
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
J.Med.Chem., 55, 2012
4E6D
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BU of 4e6d by Molmil
JAK2 kinase (JH1 domain) triple mutant in complex with compound 7
Descriptor: 3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:Murray, J.M.
Deposit date:2012-03-15
Release date:2012-05-30
Last modified:2023-03-01
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
J.Med.Chem., 55, 2012
4E6Q
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BU of 4e6q by Molmil
JAK2 kinase (JH1 domain) triple mutant in complex with compound 12
Descriptor: 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK2
Authors:Murray, J.M.
Deposit date:2012-03-15
Release date:2012-05-30
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
J.Med.Chem., 55, 2012

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数据于2024-07-10公开中

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