Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7V7W
DownloadVisualize
BU of 7v7w by Molmil
Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA)
Descriptor: (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha
Authors:Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D.
Deposit date:2021-08-21
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.507 Å)
Cite:Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
9FXM
DownloadVisualize
BU of 9fxm by Molmil
TRPC4 in complex with Z-AzPico
Descriptor: (Z)-7-(4-chlorobenzyl)-1-(3-hydroxypropyl)-3-methyl-8-(4-(phenyldiazenyl)-3-(trifluoromethoxy)phenoxy)-3,7-dihydro-1H-purine-2,6-dione, Transient receptor potential cation channel subfamily c member 4a
Authors:Vinayagam, D, Raunser, S.
Deposit date:2024-07-01
Release date:2025-07-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:TRPC4 in complex with Z-AzPico
To Be Published
4FLI
DownloadVisualize
BU of 4fli by Molmil
Human MetAP1 with bengamide analog Y16, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ...
Authors:Ye, Q.Z, Xu, W.
Deposit date:2012-06-14
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J.Med.Chem., 55, 2012
4FLJ
DownloadVisualize
BU of 4flj by Molmil
Human MetAP1 with bengamide analog Y08, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ...
Authors:Ye, Q.Z, Xu, W.
Deposit date:2012-06-14
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J.Med.Chem., 55, 2012
4FLL
DownloadVisualize
BU of 4fll by Molmil
Human MetAP1 with bengamide analog YZ6, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ...
Authors:Ye, Q.Z, Xu, W.
Deposit date:2012-06-14
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J.Med.Chem., 55, 2012
1FJ5
DownloadVisualize
BU of 1fj5 by Molmil
TAMOXIFEN-DNA ADDUCT
Descriptor: (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINIUM, DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3')
Authors:Shimotakahara, S, Gorin, A, Kolbanovskiy, A, Kettani, A, Hingerty, B.E, Amin, S, Broyde, S, Geacintov, N, Patel, D.J.
Deposit date:2000-08-07
Release date:2000-09-11
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove.
J.Mol.Biol., 302, 2000
4FLK
DownloadVisualize
BU of 4flk by Molmil
Human MetAP1 with bengamide analog Y10, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ...
Authors:Ye, Q.Z, Xu, W.
Deposit date:2012-06-14
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J.Med.Chem., 55, 2012
3ODL
DownloadVisualize
BU of 3odl by Molmil
Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247
Descriptor: Cyclophilin A, Voclosporin
Authors:Kuglstatter, A, Stihle, M, Benz, J, Hennig, M.
Deposit date:2010-08-11
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).
Acta Crystallogr.,Sect.D, 67, 2011
7CN3
DownloadVisualize
BU of 7cn3 by Molmil
2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid
Descriptor: (~{Z})-4-formamido-4-oxidanylidene-but-2-enoic acid, 1,2-ETHANEDIOL, 2,5-dihydroxypyridine 5,6-dioxygenase, ...
Authors:Liu, G.Q, Tang, H.Z.
Deposit date:2020-07-30
Release date:2020-12-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid
Nat Commun, 2020
3PKD
DownloadVisualize
BU of 3pkd by Molmil
M. tuberculosis MetAP with bengamide analog Y10, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase
Authors:Ye, Q.Z, Lu, J.P.
Deposit date:2010-11-11
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKC
DownloadVisualize
BU of 3pkc by Molmil
M. tuberculosis MetAP with bengamide analog Y08, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase
Authors:Ye, Q.Z, Lu, J.P.
Deposit date:2010-11-11
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKE
DownloadVisualize
BU of 3pke by Molmil
M. tuberculosis MetAP with bengamide analog Y10, in Ni form
Descriptor: (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, CHLORIDE ION, Methionine aminopeptidase, ...
Authors:Ye, Q.Z, Lu, J.P.
Deposit date:2010-11-11
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKB
DownloadVisualize
BU of 3pkb by Molmil
M. tuberculosis MetAP with bengamide analog Y16, in Mn form
Descriptor: (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Ye, Q.Z, Lu, J.P.
Deposit date:2010-11-11
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
4TXP
DownloadVisualize
BU of 4txp by Molmil
Crystal structure of LIP5 N-terminal domain
Descriptor: Vacuolar protein sorting-associated protein VTA1 homolog
Authors:Vild, C.J, Xu, Z.
Deposit date:2014-07-04
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:A Novel Mechanism of Regulating the ATPase VPS4 by Its Cofactor LIP5 and the Endosomal Sorting Complex Required for Transport (ESCRT)-III Protein CHMP5.
J.Biol.Chem., 290, 2015
4TZ3
DownloadVisualize
BU of 4tz3 by Molmil
Ensemble refinement of the E502A variant of sacteLam55A from Streptomyces sp. SirexAA-E in complex with laminaritetraose
Descriptor: 1,2-ETHANEDIOL, Putative secreted protein, beta-D-glucopyranose, ...
Authors:Bianchetti, C.M, Takasuka, T.E, Yik, E.J, Bergeman, L.F, Fox, B.G.
Deposit date:2014-07-09
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Active site and laminarin binding in glycoside hydrolase family 55.
J.Biol.Chem., 290, 2015
4TZ1
DownloadVisualize
BU of 4tz1 by Molmil
Ensemble refinement of the E502A variant of sacteLam55A from Streptomyces sp. SirexAA-E in complex with laminaritriose
Descriptor: Putative secreted protein, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose
Authors:Bianchetti, C.M, Takasuka, T.E, Yik, E.J, Bergeman, L.F, Fox, B.G.
Deposit date:2014-07-09
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Active site and laminarin binding in glycoside hydrolase family 55.
J.Biol.Chem., 290, 2015
4V69
DownloadVisualize
BU of 4v69 by Molmil
Ternary complex-bound E.coli 70S ribosome.
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Villa, E, Sengupta, J, Trabuco, L.G, LeBarron, J, Baxter, W.T, Shaikh, T.R, Grassucci, R.A, Nissen, P, Ehrenberg, M, Schulten, K, Frank, J.
Deposit date:2008-12-11
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
Proc.Natl.Acad.Sci.USA, 106, 2009
9BC7
DownloadVisualize
BU of 9bc7 by Molmil
HCN1 M305L holo
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Kim, E.D, Nimigean, C.M.
Deposit date:2024-04-08
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
9BC6
DownloadVisualize
BU of 9bc6 by Molmil
HCN1 M305L with propofol
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Kim, E.D, Nimigean, C.M.
Deposit date:2024-04-07
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
1KPR
DownloadVisualize
BU of 1kpr by Molmil
The human non-classical major histocompatibility complex molecule HLA-E
Descriptor: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN, ...
Authors:Holmes, M.A, Strong, R.K.
Deposit date:2002-01-02
Release date:2003-02-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:HLA-E allelic variants: Correlating differential expression, peptide affinities, crystal structures and thermal stabilities
J.Biol.Chem., 278, 2003
1KG3
DownloadVisualize
BU of 1kg3 by Molmil
Crystal structure of the core fragment of MutY from E.coli at 1.55A resolution
Descriptor: A/G-specific adenine glycosylase, GLYCEROL, IRON/SULFUR CLUSTER, ...
Authors:Gilboa, R, Kilshtein, A, Zharkov, D.O, Kycia, J.H, Gerchman, S.E, Grollman, A.P, Shoham, G.
Deposit date:2001-11-26
Release date:2002-11-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Analysis of the E.coli MutY DNA glycosylase structure and function by site-directed mutagenesis
To be Published
7QP5
DownloadVisualize
BU of 7qp5 by Molmil
Crystal Structure of E. coli FhuF
Descriptor: FE2/S2 (INORGANIC) CLUSTER, Ferric iron reductase protein FhuF
Authors:Trindade, I.B, Rollo, F, Matias, P.M, Moe, E, Louro, R.O.
Deposit date:2022-01-03
Release date:2023-07-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The structure of a novel ferredoxin: FhuF, a ferric-siderophore reductase from E. coli K-12 with a novel 2Fe-2S cluster coordination
Biorxiv, 2023
5K0I
DownloadVisualize
BU of 5k0i by Molmil
mpges1 bound to an inhibitor
Descriptor: 1,5-anhydro-2,3,4-trideoxy-3-{[(4S)-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}-D-erythro-hexitol, GLUTATHIONE, Prostaglandin E synthase, ...
Authors:Luz, J.G, Kuklish, S.L.
Deposit date:2016-05-17
Release date:2016-09-14
Last modified:2025-04-02
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5XQ5
DownloadVisualize
BU of 5xq5 by Molmil
NMR structure of the domain 5 of the E. coli ribosomal protein S1
Descriptor: 30S ribosomal protein S1
Authors:Lu, Y, Lim, L.Z, Song, J.
Deposit date:2017-06-06
Release date:2018-06-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR structure of the domain 5 of the E. coli ribosomal protein S1
To Be Published
6TI9
DownloadVisualize
BU of 6ti9 by Molmil
Human transthyretin (TTR) complexed with (E)-3-(((3,5-dibromo-2-hydroxybenzylidene)amino)oxy)propanoic acid.
Descriptor: 3-[(~{E})-[3,5-bis(bromanyl)-2-oxidanyl-phenyl]methylideneamino]oxypropanoic acid, GLYCEROL, S-1,2-PROPANEDIOL, ...
Authors:Ciccone, L, Nencetti, S, Orlandini, E, Rossello, A, Legrand, P, Shepard, W.
Deposit date:2019-11-22
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.
Bioorg.Med.Chem., 28, 2020

238582

数据于2025-07-09公开中

PDB statisticsPDBj update infoContact PDBjnumon