7Y58
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4R86
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![BU of 4r86 by Molmil](/molmil-images/mine/4r86) | Crystal Structure of Aminoglycoside/Multidrug Efflux System AcrD from Salmonella typhimurium | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kim, Y, Maltseva, N, Shatsman, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-08-29 | Release date: | 2014-10-08 | Last modified: | 2016-10-12 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | Crystal Structure of Aminoglycoside/Multidrug Efflux System AcrD from
Salmonella typhimurium To be Published
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4Z3P
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![BU of 4z3p by Molmil](/molmil-images/mine/4z3p) | MATE transporter ClbM in complex with Rb+ | Descriptor: | CACODYLATE ION, Putative drug/sodium antiporter, RUBIDIUM ION | Authors: | Mousa, J.J, Bruner, S.D. | Deposit date: | 2015-03-31 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | MATE transport of the E. coli-derived genotoxin colibactin. Nat Microbiol, 1, 2016
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4Z3N
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![BU of 4z3n by Molmil](/molmil-images/mine/4z3n) | Crystal structure of the MATE transporter ClbM | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CACODYLATE ION, Putative drug/sodium antiporter | Authors: | Mousa, J.J, Bruner, S.D. | Deposit date: | 2015-03-31 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | MATE transport of the E. coli-derived genotoxin colibactin. Nat Microbiol, 1, 2016
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5C6N
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![BU of 5c6n by Molmil](/molmil-images/mine/5c6n) | protein A | Descriptor: | BH2163 protein | Authors: | Lu, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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5C6P
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![BU of 5c6p by Molmil](/molmil-images/mine/5c6p) | protein C | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, protein C, protein D | Authors: | Lu, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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5C6O
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![BU of 5c6o by Molmil](/molmil-images/mine/5c6o) | protein B | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, BH2163 protein | Authors: | Lu, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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8SX8
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8SXB
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8SX7
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8IZR
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![BU of 8izr by Molmil](/molmil-images/mine/8izr) | Multidrug resistance-associated protein 3 | Descriptor: | ATP-binding cassette sub-family C member 2 | Authors: | Yun, C.H, Gao, H.M. | Deposit date: | 2023-04-07 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | structure of multidrug resistance-associated protein 2 at 3.62 Angstroms resolution To Be Published
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8IZP
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![BU of 8izp by Molmil](/molmil-images/mine/8izp) | Multidrug resistance-associated protein 3 | Descriptor: | ATP-binding cassette sub-family C member 3 | Authors: | Yun, C.H, Gao, H.M. | Deposit date: | 2023-04-07 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | structure of multidrug resistance-associated protein 3 at 3.31 Angstroms To Be Published
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6IOK
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![BU of 6iok by Molmil](/molmil-images/mine/6iok) | Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | Descriptor: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | Authors: | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2019-04-17 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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6IOL
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![BU of 6iol by Molmil](/molmil-images/mine/6iol) | Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | Descriptor: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | Authors: | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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5T0O
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![BU of 5t0o by Molmil](/molmil-images/mine/5t0o) | Crystal Structure of a membrane protein | Descriptor: | CmeB | Authors: | Su, C.-C, Yu, E.W. | Deposit date: | 2016-08-16 | Release date: | 2017-09-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump. Nat Commun, 8, 2017
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1EXJ
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![BU of 1exj by Molmil](/molmil-images/mine/1exj) | CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPP | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, SODIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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1EXI
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![BU of 1exi by Molmil](/molmil-images/mine/1exi) | CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPSB | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, TETRAPHENYLANTIMONIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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7CZ9
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![BU of 7cz9 by Molmil](/molmil-images/mine/7cz9) | Crystal structure of multidrug efflux transporter OqxB from Klebsiella pneumoniae | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter, GLYCEROL, ... | Authors: | Murakami, S, Okada, U, Yamashita, E. | Deposit date: | 2020-09-07 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae. Nat Commun, 12, 2021
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5AZS
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4CDI
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![BU of 4cdi by Molmil](/molmil-images/mine/4cdi) | Crystal structure of AcrB-AcrZ complex | Descriptor: | ACRIFLAVINE RESISTANCE PROTEIN B, PREDICTED PROTEIN | Authors: | Du, D, James, N, Klimont, E, Luisi, B.F. | Deposit date: | 2013-10-31 | Release date: | 2014-04-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure of the Acrab-Tolc Multidrug Efflux Pump. Nature, 509, 2014
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4C48
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![BU of 4c48 by Molmil](/molmil-images/mine/4c48) | Crystal structure of AcrB-AcrZ complex | Descriptor: | ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Du, D, James, N, Klimont, E, Luisi, B.F. | Deposit date: | 2013-09-02 | Release date: | 2014-04-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the AcrAB-TolC multidrug efflux pump. Nature, 509, 2014
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2W1B
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![BU of 2w1b by Molmil](/molmil-images/mine/2w1b) | The structure of the efflux pump AcrB in complex with bile acid | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACRIFLAVIN RESISTANCE PROTEIN B | Authors: | Drew, D, Klepsch, M.M, Newstead, S, Flaig, R, De Gier, J.W, Iwata, S, Beis, K. | Deposit date: | 2008-10-17 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | The Structure of the Efflux Pump Acrb in Complex with Bile Acid. Mol.Membr.Biol., 25, 2008
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8WI2
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![BU of 8wi2 by Molmil](/molmil-images/mine/8wi2) | RD-hMRP5-inward open | Descriptor: | ATP-binding cassette sub-family C member 5, CYS-GLN-ASP-ALA-LEU-GLU-THR-ALA-ALA-ARG-ALA-GLU-GLY-LEU-SER-LEU-ASP-ALA-SER | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI3
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![BU of 8wi3 by Molmil](/molmil-images/mine/8wi3) | ND-hMRP5-inward open | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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8WI0
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![BU of 8wi0 by Molmil](/molmil-images/mine/8wi0) | wt-hMRP5 inward-open | Descriptor: | ATP-binding cassette sub-family C member 5 | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-09-24 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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