5FKY
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![BU of 5fky by Molmil](/molmil-images/mine/5fky) | Structure of a hydrolase bound with an inhibitor | Descriptor: | (3aR,5R,6S,7R,7aR)-2-amino-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, GLYCEROL, O-GLCNACASE BT_4395 | Authors: | Cekic, N, Heinonen, J.E, Stubbs, K.A, Roth, C, McEachern, E.J, Davies, G.J, Vocadlo, D.J. | Deposit date: | 2015-10-20 | Release date: | 2016-01-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase. Chem Sci, 7, 2016
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5FL1
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![BU of 5fl1 by Molmil](/molmil-images/mine/5fl1) | Structure of a hydrolase with an inhibitor | Descriptor: | (3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-5-(hydroxymethyl)-2-(prop-2-enylamino)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]thiazole-6,7-diol, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Cekic, N, Heinonen, J.E, Stubbs, K.A, Roth, C, McEachern, E.J, Davies, G.J, Vocadlo, D.J. | Deposit date: | 2015-10-20 | Release date: | 2016-08-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase. Chem Sci, 7, 2016
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5FL0
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![BU of 5fl0 by Molmil](/molmil-images/mine/5fl0) | Structure of a hydrolase with an inhibitor | Descriptor: | (3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-2-(butylamino)-5-(hydroxymethyl)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d] [1,3]thiazole-6,7-diol, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Cekic, N, Heinonen, J.E, Stubbs, K.A, Roth, C, McEachern, E.J, Davies, G.J, Vocadlo, D.J. | Deposit date: | 2015-10-20 | Release date: | 2016-08-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase. Chem Sci, 7, 2016
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5OXD
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![BU of 5oxd by Molmil](/molmil-images/mine/5oxd) | |
2WB5
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![BU of 2wb5 by Molmil](/molmil-images/mine/2wb5) | GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation | Descriptor: | (5R,6R,7R,8S)-6,7-dihydroxy-5-(hydroxymethyl)-2-(2-phenylethyl)-8-(propanoylamino)-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium, CHLORIDE ION, O-GLCNACASE NAGJ, ... | Authors: | Dorfmueller, H.C, Borodkin, V.S, Schimpl, M, van Aalten, D.M.F. | Deposit date: | 2009-02-20 | Release date: | 2009-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Glcnacstatins are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation Biochem.J., 420, 2009
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2XJ7
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![BU of 2xj7 by Molmil](/molmil-images/mine/2xj7) | BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine | Descriptor: | 6-ACETAMIDO-6-DEOXY-CASTANOSPERMINE, CALCIUM ION, O-GLCNACASE BT_4395 | Authors: | He, Y, Davies, G.J. | Deposit date: | 2010-07-02 | Release date: | 2010-09-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inhibition of O-Glcnacase Using a Potent and Cell-Permeable Inhibitor Does not Induce Insulin Resistance in 3T3-L1 Adipocytes. Chem.Biol., 17, 2010
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2X0Y
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![BU of 2x0y by Molmil](/molmil-images/mine/2x0y) | Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds | Descriptor: | 7-[(2S)-2,3-DIHYDROXYPROPYL]-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, O-GLCNACASE NAGJ | Authors: | Dorfmueller, H.C, van Aalten, D.M.F. | Deposit date: | 2009-12-18 | Release date: | 2010-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Screening-Based Discovery of Drug-Like O-Glcnacase Inhibitor Scaffolds FEBS Lett., 584, 2010
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2XM2
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![BU of 2xm2 by Molmil](/molmil-images/mine/2xm2) | BtGH84 in complex with LOGNAc | Descriptor: | GLYCEROL, N-acetylglucosaminono-1,5-lactone (Z)-oxime, O-GLCNACASE BT_4395 | Authors: | He, Y, Davies, G.J. | Deposit date: | 2010-07-22 | Release date: | 2011-08-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Inhibition of a Bacterial O-Glcnacase Homologue by Lactone and Lactam Derivatives: Structural, Kinetic and Thermodynamic Analyses. Amino Acids, 40, 2011
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2XM1
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![BU of 2xm1 by Molmil](/molmil-images/mine/2xm1) | BtGH84 in complex with N-acetyl gluconolactam | Descriptor: | GLYCEROL, N-ACETYL GLUCONOLACTAM, O-GLCNACASE BT_4395 | Authors: | He, Y, Davies, G.J. | Deposit date: | 2010-07-22 | Release date: | 2011-08-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inhibition of a Bacterial O-Glcnacase Homologue by Lactone and Lactam Derivatives: Structural, Kinetic and Thermodynamic Analyses. Amino Acids, 40, 2011
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2XPK
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![BU of 2xpk by Molmil](/molmil-images/mine/2xpk) | Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases | Descriptor: | N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE, O-GLCNACASE NAGJ | Authors: | Dorfmueller, H.C, Borodkin, V.S, Schimpl, M, Zheng, X, Kime, R, Read, K.D, van Aalten, D.M.F. | Deposit date: | 2010-08-26 | Release date: | 2011-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cell-Penetrant, Nanomolar O-Glcnacase Inhibitors Selective Against Lysosomal Hexosaminidases. Chem.Biol, 17, 2010
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2WZH
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![BU of 2wzh by Molmil](/molmil-images/mine/2wzh) | BtGH84 D242N in complex with MeUMB-derived oxazoline | Descriptor: | 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, CALCIUM ION, GLYCEROL, ... | Authors: | He, Y, Davies, G.J. | Deposit date: | 2009-11-30 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase J.Am.Chem.Soc., 132, 2010
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2X0H
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![BU of 2x0h by Molmil](/molmil-images/mine/2x0h) | BtGH84 Michaelis complex | Descriptor: | 3,4-difluorophenyl 2-deoxy-2-[(difluoroacetyl)amino]-beta-D-glucopyranoside, CALCIUM ION, GLYCEROL, ... | Authors: | He, Y, Davies, G.J. | Deposit date: | 2009-12-08 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase J.Am.Chem.Soc., 132, 2010
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2WZI
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![BU of 2wzi by Molmil](/molmil-images/mine/2wzi) | BtGH84 D243N in complex with 5F-oxazoline | Descriptor: | (3AS,5S,6S,7R,7AR)-5-FLUORO-5-(HYDROXYMETHYL)-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]OXAZOLE-6,7-DIOL, CALCIUM ION, GLYCEROL, ... | Authors: | He, Y, Davies, G.J. | Deposit date: | 2009-11-30 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Visualizing the Reaction Coordinate of an O-Glcnac Hydrolase J.Am.Chem.Soc., 132, 2010
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1R3E
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![BU of 1r3e by Molmil](/molmil-images/mine/1r3e) | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | Descriptor: | 5'-R(*CP*UP*GP*UP*GP*UP*(FHU)P*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', 5'-R(*CP*UP*GP*UP*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', tRNA pseudouridine synthase B | Authors: | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2003-10-01 | Release date: | 2003-11-04 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit Proc.Natl.Acad.Sci.USA, 100, 2003
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5LAD
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![BU of 5lad by Molmil](/molmil-images/mine/5lad) | |
6Q44
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![BU of 6q44 by Molmil](/molmil-images/mine/6q44) | Est3 telomerase subunit in the yeast Hansenula polymorpha | Descriptor: | Uncharacterized protein | Authors: | Mantsyzov, A.B, Mariasina, S.S, Petrova, O.A, Efimov, S.V, Dontsova, O.A, Polshakov, V.I. | Deposit date: | 2018-12-05 | Release date: | 2019-12-25 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase. Sci Rep, 10, 2020
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2AZL
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![BU of 2azl by Molmil](/molmil-images/mine/2azl) | Crystal structure for the mutant F117E of Thermotoga maritima octaprenyl pyrophosphate synthase | Descriptor: | octoprenyl-diphosphate synthase | Authors: | Sun, H.Y, Ko, T.P, Kuo, C.J, Guo, R.T, Chou, C.C, Liang, P.H, Wang, A.H. | Deposit date: | 2005-09-12 | Release date: | 2006-03-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures J.Bacteriol., 187, 2005
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2H2I
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![BU of 2h2i by Molmil](/molmil-images/mine/2h2i) | The Structural basis of Sirtuin Substrate Affinity | Descriptor: | (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, NAD-dependent deacetylase, ZINC ION | Authors: | Cosgrove, M.S, Wolberger, C. | Deposit date: | 2006-05-18 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of sirtuin substrate affinity Biochemistry, 45, 2006
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2KA0
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![BU of 2ka0 by Molmil](/molmil-images/mine/2ka0) | NMR structure of the protein TM1367 | Descriptor: | uncharacterized protein TM1367 | Authors: | Mohanty, B, Pedrini, B, Serrano, P, Geralt, M, Horst, R, Herrmann, T, Wilson, I.A, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2008-10-27 | Release date: | 2009-01-13 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Comparison of NMR and crystal structures for the proteins TM1112 and TM1367. Acta Crystallogr.,Sect.F, 66, 2010
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2H2H
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![BU of 2h2h by Molmil](/molmil-images/mine/2h2h) | |
2H2D
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![BU of 2h2d by Molmil](/molmil-images/mine/2h2d) | |
2H2F
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![BU of 2h2f by Molmil](/molmil-images/mine/2h2f) | |
2KA5
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![BU of 2ka5 by Molmil](/molmil-images/mine/2ka5) | NMR Structure of the protein TM1081 | Descriptor: | Putative anti-sigma factor antagonist TM_1081 | Authors: | Serrano, P, Geralt, M, Mohanty, B, Pedrini, B, Horst, R, Wuthrich, K, Wilson, I, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2008-10-30 | Release date: | 2008-11-25 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites. Acta Crystallogr.,Sect.F, 66, 2010
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1WA3
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![BU of 1wa3 by Molmil](/molmil-images/mine/1wa3) | Mechanism of the Class I KDPG aldolase | Descriptor: | 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE ALDOLASE, PYRUVIC ACID, SULFATE ION | Authors: | Fullerton, S.W.B, Griffiths, J.S, Merkel, A.B, Wymer, N.J, Hutchins, M.J, Fierke, C.A, Toone, E.J, Naismith, J.H. | Deposit date: | 2004-10-22 | Release date: | 2005-01-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of the Class I Kdpg Aldolase. Bioorg.Med.Chem., 14, 2006
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1LW4
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![BU of 1lw4 by Molmil](/molmil-images/mine/1lw4) | |