5FL1

Structure of a hydrolase with an inhibitor

Summary for 5FL1

Entry DOI	10.2210/pdb5fl1/pdb
Related	5FKY 5FL0
Descriptor	O-GLCNACASE BT_4395, (3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-5-(hydroxymethyl)-2-(prop-2-enylamino)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]thiazole-6,7-diol, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	BACTEROIDES THETAIOTAOMICRON
Total number of polymer chains	2
Total formula weight	165441.19
Authors	Cekic, N.,Heinonen, J.E.,Stubbs, K.A.,Roth, C.,McEachern, E.J.,Davies, G.J.,Vocadlo, D.J. (deposition date: 2015-10-20, release date: 2016-08-31, Last modification date: 2018-08-29)
Primary citation	Cekic, N.,Heinonen, J.E.,Stubbs, K.A.,Roth, C.,He, Y.,Bennet, A.J.,McEachern, E.J.,Davies, G.J.,Vocadlo, D.J. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase. Chem Sci, 7:3742-3750, 2016 Cited by PubMed: 29997861 DOI: 10.1039/c6sc00370b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation