2XPK
Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases
Summary for 2XPK
Entry DOI | 10.2210/pdb2xpk/pdb |
Related | 2CBI 2CBJ 2J62 2JH2 2V5C 2V5D 2VUR 2WB5 2X0Y |
Descriptor | O-GLCNACASE NAGJ, N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE (3 entities in total) |
Functional Keywords | hydrolase, signalling |
Biological source | CLOSTRIDIUM PERFRINGENS |
Total number of polymer chains | 2 |
Total formula weight | 134170.38 |
Authors | Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Zheng, X.,Kime, R.,Read, K.D.,van Aalten, D.M.F. (deposition date: 2010-08-26, release date: 2011-03-16, Last modification date: 2023-12-20) |
Primary citation | Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Zheng, X.,Kime, R.,Read, K.D.,Van Aalten, D.M.F. Cell-Penetrant, Nanomolar O-Glcnacase Inhibitors Selective Against Lysosomal Hexosaminidases. Chem.Biol, 17:1250-, 2010 Cited by PubMed: 21095575DOI: 10.1016/J.CHEMBIOL.2010.09.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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