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2XPK

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Summary for 2XPK
Entry DOI10.2210/pdb2xpk/pdb
Related2CBI 2CBJ 2J62 2JH2 2V5C 2V5D 2VUR 2WB5 2X0Y
DescriptorO-GLCNACASE NAGJ, N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE (3 entities in total)
Functional Keywordshydrolase, signalling
Biological sourceCLOSTRIDIUM PERFRINGENS
Total number of polymer chains2
Total formula weight134170.38
Authors
Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Zheng, X.,Kime, R.,Read, K.D.,van Aalten, D.M.F. (deposition date: 2010-08-26, release date: 2011-03-16, Last modification date: 2023-12-20)
Primary citationDorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Zheng, X.,Kime, R.,Read, K.D.,Van Aalten, D.M.F.
Cell-Penetrant, Nanomolar O-Glcnacase Inhibitors Selective Against Lysosomal Hexosaminidases.
Chem.Biol, 17:1250-, 2010
Cited by
PubMed: 21095575
DOI: 10.1016/J.CHEMBIOL.2010.09.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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