1A6V
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7CZD
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![BU of 7czd by Molmil](/molmil-images/mine/7czd) | Crystal structure of PD-L1 in complex with a VHH | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ... | Authors: | Wang, C. | Deposit date: | 2020-09-08 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
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1A64
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1A6P
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1BFV
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![BU of 1bfv by Molmil](/molmil-images/mine/1bfv) | MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI | Descriptor: | ESTRIOL 3-(B-D-GLUCURONIDE), FV4155, ZINC ION | Authors: | Trinh, C.H, Phillips, S.E.V. | Deposit date: | 1997-05-27 | Release date: | 1997-12-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity. Structure, 5, 1997
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7BEA
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![BU of 7bea by Molmil](/molmil-images/mine/7bea) | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | Deposit date: | 2020-12-22 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
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1AR2
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![BU of 1ar2 by Molmil](/molmil-images/mine/1ar2) | DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT | Descriptor: | REI | Authors: | Uson, I, Bes, M.T, Sheldrick, G.M, Schneider, T.R, Hartsch, T, Fritz, H.-J. | Deposit date: | 1997-08-08 | Release date: | 1997-11-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray crystallography reveals stringent conservation of protein fold after removal of the only disulfide bridge from a stabilized immunoglobulin variable domain. Structure Fold.Des., 2, 1997
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7ELX
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![BU of 7elx by Molmil](/molmil-images/mine/7elx) | The crystal structure of CTLA-4 and Fab | Descriptor: | Cytotoxic T-lymphocyte protein 4, heavy chain of Fab, light chain of Fab | Authors: | Yu, X.J, Wang, L, Yu, C.F. | Deposit date: | 2021-04-12 | Release date: | 2021-06-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | The crystal structure of CTLA-4 and Fab To Be Published
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2YWY
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7E9B
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2ZG1
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7DV4
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![BU of 7dv4 by Molmil](/molmil-images/mine/7dv4) | Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 | Descriptor: | 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 | Authors: | Li, H, Gan, X, He, Y. | Deposit date: | 2021-01-12 | Release date: | 2022-01-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119, 2022
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7DY7
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![BU of 7dy7 by Molmil](/molmil-images/mine/7dy7) | Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation | Descriptor: | 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1 | Authors: | Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B. | Deposit date: | 2021-01-20 | Release date: | 2022-01-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem., 65, 2022
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3B5T
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![BU of 3b5t by Molmil](/molmil-images/mine/3b5t) | Crystal Structure of Novel Immune-Type Receptor 10 Se-Met Extracellular Fragment Mutant N30D | Descriptor: | Novel immune-type receptor 10 | Authors: | Ostrov, D.A, Hernandez Prada, J.A, Haire, R.N, Cannon, J.P, Magis, A.T, Bailey, K.M, Litman, G.W. | Deposit date: | 2007-10-26 | Release date: | 2008-06-24 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity, 29, 2008
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3BIA
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![BU of 3bia by Molmil](/molmil-images/mine/3bia) | Tim-4 in complex with sodium potassium tartrate | Descriptor: | L(+)-TARTARIC ACID, SODIUM ION, T-cell immunoglobulin and mucin domain-containing protein 4 | Authors: | Santiago, C, Ballesteros, A, Kaplan, G.G, Freeman, G.J, Casasnovas, J.M. | Deposit date: | 2007-11-30 | Release date: | 2008-01-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds. Immunity, 27, 2007
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2ZG3
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3BDX
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![BU of 3bdx by Molmil](/molmil-images/mine/3bdx) | Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, Amyloid lambda 6 light chain variable region PIP (fragment), ... | Authors: | Hernandez-Santoyo, A, Fuentes-Silva, D, Del Pozo Yauner, L, Becerril, B, Rodriguez-Romero, A. | Deposit date: | 2007-11-15 | Release date: | 2008-10-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis. J.Mol.Biol., 396, 2010
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3B9K
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![BU of 3b9k by Molmil](/molmil-images/mine/3b9k) | Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab Light Chain, ... | Authors: | Shore, D, Wilson, I.A. | Deposit date: | 2007-11-05 | Release date: | 2008-11-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Crystal Structure of CD8 in Complex with YTS156.7.7 Fab and Interaction with Other CD8 Antibodies Define the Binding Mode of CD8 alphabeta to MHC Class I J.Mol.Biol., 384, 2008
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2Z35
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![BU of 2z35 by Molmil](/molmil-images/mine/2z35) | Crystal structure of immune receptor | Descriptor: | T-cell receptor alpha-chain, T-cell receptor beta-chain | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-06-01 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
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3BDB
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![BU of 3bdb by Molmil](/molmil-images/mine/3bdb) | Crystal Structure of Novel Immune-Type Receptor 11 Extracellular Fragment from Ictalurus punctatus including Stalk Region | Descriptor: | Novel immune-type receptor 11 | Authors: | Ostrov, D.A, Hernandez Prada, J.A, Haire, R.N, Cannon, J.P, Magis, A.T, Bailey, K.M, Litman, G.W. | Deposit date: | 2007-11-14 | Release date: | 2008-06-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity, 29, 2008
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3BJ9
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![BU of 3bj9 by Molmil](/molmil-images/mine/3bj9) | Crystal structure of the Surrogate Light Chain Variable Domain VpreBJ | Descriptor: | 1,2-ETHANEDIOL, Immunoglobulin iota chain, Immunoglobulin lambda-like polypeptide 1 | Authors: | Morstadt, L.M, Bohm, A.A, Stollar, B.D, Baleja, J.D. | Deposit date: | 2007-12-03 | Release date: | 2008-03-04 | Last modified: | 2019-09-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineering and characterization of a single chain surrogate light chain variable domain. Protein Sci., 17, 2008
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3BI9
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![BU of 3bi9 by Molmil](/molmil-images/mine/3bi9) | Tim-4 | Descriptor: | ACETATE ION, T-cell immunoglobulin and mucin domain-containing protein 4 | Authors: | Santiago, C, Ballesteros, A, Kaplan, G.G, Freeman, G.J, Casasnovas, J.M. | Deposit date: | 2007-11-30 | Release date: | 2008-01-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds. Immunity, 27, 2007
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3BIB
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![BU of 3bib by Molmil](/molmil-images/mine/3bib) | Tim-4 in complex with phosphatidylserine | Descriptor: | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, SODIUM ION, T-cell immunoglobulin and mucin domain-containing protein 4 | Authors: | Santiago, C, Ballesteros, A, Kaplan, G.G, Freeman, G.J, Casasnovas, J.M. | Deposit date: | 2007-11-30 | Release date: | 2008-01-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds. Immunity, 27, 2007
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6SRU
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![BU of 6sru by Molmil](/molmil-images/mine/6sru) | Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1) | Descriptor: | Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A. | Deposit date: | 2019-09-06 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.532 Å) | Cite: | Human and mouse PD-L1: similar molecular structure, but different druggability profiles. Iscience, 24, 2021
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6U6V
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![BU of 6u6v by Molmil](/molmil-images/mine/6u6v) | Crystal structure of human PD-1H / VISTA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, V-type immunoglobulin domain-containing suppressor of T-cell activation | Authors: | Slater, B.T, Han, X, Chen, L, Xiong, Y. | Deposit date: | 2019-08-30 | Release date: | 2020-01-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insight into T cell coinhibition by PD-1H (VISTA). Proc.Natl.Acad.Sci.USA, 117, 2020
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