2ZG3

Crystal Structure of Two N-terminal Domains of Native Siglec-5 in Complex with 3'-Sialyllactose

Summary for 2ZG3

Entry DOI	10.2210/pdb2zg3/pdb
Related	1O7S 1QFO 2ZG1 2ZG2
Descriptor	Sialic acid-binding Ig-like lectin 5, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose (3 entities in total)
Functional Keywords	siglec-5 inhibitory receptor, two-domain structure, v-set, c2-set, ig-like domain, sialic acid, 3'-sialyllactose complex, cell adhesion, glycoprotein, immunoglobulin domain, lectin, membrane, polymorphism, transmembrane, immune system-carbohydrate binding protein complex, immune system/carbohydrate binding protein
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: O15389
Total number of polymer chains	1
Total formula weight	24965.91
Authors	Zhuravleva, M.A.,Sun, P.D. (deposition date: 2008-01-17, release date: 2008-02-05, Last modification date: 2023-11-01)
Primary citation	Zhuravleva, M.A.,Trandem, K.,Sun, P.D. Structural implications of Siglec-5-mediated sialoglycan recognition J.Mol.Biol., 375:437-447, 2008 Cited by PubMed: 18022638 DOI: 10.1016/j.jmb.2007.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation