Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2

Summary for 3BDX

DescriptorAmyloid lambda 6 light chain variable region PIP (fragment), ACETATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywordslambda vi subgroup, light chain variable domain, beta-sandwich, immunoglobulin, al amyloidosis, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight36714.45
Hernandez-Santoyo, A.,Fuentes-Silva, D.,Del Pozo Yauner, L.,Becerril, B.,Rodriguez-Romero, A. (deposition date: 2007-11-15, release date: 2008-10-28, Last modification date: 2011-07-13)
Primary citation
Hernandez-Santoyo, A.,del Pozo Yauner, L.,Fuentes-Silva, D.,Ortiz, E.,Rudino-Pinera, E.,Sanchez-Lopez, R.,Horjales, E.,Becerril, B.,Rodriguez-Romero, A.
A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis.
J.Mol.Biol., 396:280-292, 2010
PubMed: 19941869 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.11.038
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253130.6%3.7%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16