3BDX
Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Amyloid lambda 6 light chain variable region PIP (fragment) | polymer | 111 | 11951.9 | 3 | UniProt (Q96JD1) Pfam (PF07686) | Homo sapiens (Human) | Recombinant light chain variable domain |
| 2 | D, E, F, I, L (A, B, C) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 3 | G, H, J, M (A, B, C) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | K (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | N, O, P (A, B, C) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 111 (UniProt: Q96JD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | Pro 7 | engineered mutation |
| Val 18 | Ile 18 | conflict |
| Ser 44 | Ala 44 | conflict |
| Ser 97 | Asn 97 | conflict |
| His 99 | Tyr 99 | conflict |
| Val 100 | Ala 100 | conflict |
| Val 101 | Leu 101 | conflict |
| Lys 107 | Gln 107 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35855.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 858.8 | |
| All* | Total formula weight | 36714.5 |
