PDB: 46188 resultsInfo pagesStatus searchChemie searchBIRD

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8SCZ	Cryo-EM structure of 14aa-GS RIG-I in complex with p3SLR30 Descriptor: Antiviral innate immune response receptor RIG-I, ZINC ION, p3SLR30 Authors: Wang, W, Pyle, A.M. Deposit date: 2023-04-06 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryo-EM structure of 14aa-GS RIG-I in complex with p3SLR30 To Be Published
3VIB	Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, MtrR, PHOSPHATE ION Authors: Kumaraswami, M, Shafer, W.M, Brennan, R.G. Deposit date: 2011-09-27 Release date: 2012-10-03 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for multidrug recognitionand antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae TO BE PUBLISHED
8S5I	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, single particle reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5L	Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5J	Full-length human cystathionine beta-synthase, basal state, helical reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
1OT3	Crystal structure of Drosophila deoxyribonucleotide kinase complexed with the substrate deoxythymidine Descriptor: Deoxyribonucleoside Kinase, SULFATE ION, THYMIDINE Authors: Mikkelsen, N.E, Johansson, K, Karlsson, A, Knecht, W, Andersen, G, Piskur, J, Munch-Petersen, B, Eklund, H. Deposit date: 2003-03-21 Release date: 2003-05-27 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway: Studies of the Drosophila Deoxyribonucleoside Kinase. Biochemistry, 42, 2003
8SD0	Cryo-EM structure of RIG-I in complex with p3SLR14 Descriptor: Antiviral innate immune response receptor RIG-I, ZINC ION, p3SLR14 Authors: Wang, W, Pyle, A.M. Deposit date: 2023-04-06 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structure of RIG-I in complex with p3SLR14 To Be Published
8S5K	Full-length human cystathionine beta-synthase, basal state, single particle reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
1OZ1	P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR Descriptor: 3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL, Mitogen-activated protein kinase 14 Authors: Lovejoy, B, Villasenor, A, Browner, M, Dunten, P. Deposit date: 2003-04-07 Release date: 2003-09-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase. J.Med.Chem., 46, 2003
8S5H	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
3IW6	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol Descriptor: Mitogen-activated protein kinase 14, ethyl 4-[(4-benzylpiperazin-1-yl)carbonyl]-1-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylate, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Rauh, D. Deposit date: 2009-09-02 Release date: 2009-11-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
3EF9	Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability Descriptor: SULFATE ION, Thymidylate synthase Authors: Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. Deposit date: 2008-09-08 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
3N6N	crystal structure of EV71 RdRp in complex with Br-UTP Descriptor: 5-bromouridine 5'-(tetrahydrogen triphosphate), NICKEL (II) ION, RNA-dependent RNA polymerase Authors: Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. Deposit date: 2010-05-26 Release date: 2011-06-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
4UAI	Crystal structure of CXCL12 in complex with inhibitor Descriptor: 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea, SULFATE ION, Stromal cell-derived factor 1 Authors: Smith, E.W, Chen, Y. Deposit date: 2014-08-09 Release date: 2014-11-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine. J.Med.Chem., 57, 2014
8S5M	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, SAM bound, activated state, helical reconstruction Descriptor: Cystathionine beta-synthase, S-ADENOSYLMETHIONINE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (4 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
4UDS	Crystal structure of MbdR regulator from Azoarcus sp. CIB Descriptor: MBDR REGULATOR Authors: Liu, H, Liu, H.X, MacMahon, S.A, Juarez, J.F, Zamarro, M.T, Eberlein, C, Boll, M, Carmona, M, Diaz, E, Naismith, J.H. Deposit date: 2014-12-11 Release date: 2014-12-24 Last modified: 2017-09-13 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Unraveling the Specific Regulation of the Mbd Central Pathway for the Anaerobic Degradation of 3-Methylbenzoate. J.Biol.Chem., 290, 2015
1PC6	Structural Genomics, NinB Descriptor: BETA-MERCAPTOETHANOL, Protein ninB Authors: Zhang, R, Beasley, S, Maxwell, K.L, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2003-05-15 Release date: 2004-01-20 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Functional similarities between phage lambda Orf and Escherichia coli RecFOR in initiation of genetic exchange Proc.Natl.Acad.Sci.USA, 102, 2005
4UHJ	Crystal structure of the receiver domain of CpxR from E. coli (orthorhombic form) Descriptor: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR Authors: Mechaly, A.E, Alzari, P.M.A. Deposit date: 2015-03-24 Release date: 2016-04-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase. Structure, 25, 2017
3MZL	Sec13/Sec31 edge element, loop deletion mutant Descriptor: Protein transport protein SEC13, Protein transport protein SEC31 Authors: Whittle, J.R, Schwartz, T.U. Deposit date: 2010-05-12 Release date: 2010-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J.Cell Biol., 190, 2010
3N6L	The crystal structure of RNA-dependent RNA polymerase of EV71 virus Descriptor: NICKEL (II) ION, RNA-dependent RNA polymerase Authors: Wu, Y, Rao, Z.H. Deposit date: 2010-05-26 Release date: 2011-06-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
4U7A	The carboxy-terminal domain of Erb1 is a seven-bladed beta-propeller that binds RNA. Descriptor: 1,2-ETHANEDIOL, ETHANOL, GLYCEROL, ... Authors: Wegrecki, M, Bravo, J. Deposit date: 2014-07-30 Release date: 2015-04-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed -Propeller that Binds RNA. Plos One, 10, 2015
3ED7	Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability Descriptor: SULFATE ION, Thymidylate synthase Authors: Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. Deposit date: 2008-09-02 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
3NON	Crystal Structure of Isocyanide Hydratase from Pseudomonas fluorescens Descriptor: 1,2-ETHANEDIOL, Isocyanide hydratase Authors: Lakshminarasimhan, M, Madzelan, P, Nan, R, Milkovic, N.M, Wilson, M.A. Deposit date: 2010-06-25 Release date: 2010-07-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase. J.Biol.Chem., 285, 2010
4UHS	Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form) Descriptor: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR Authors: Mechaly, A.E, Alzari, P.M.A. Deposit date: 2015-03-25 Release date: 2016-04-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (5 Å) Cite: Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance. J. Struct. Biol., 204, 2018
3IW5	Human p38 MAP Kinase in Complex with an Indole Derivative Descriptor: Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Rauh, D. Deposit date: 2009-09-02 Release date: 2009-11-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009

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