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Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor
Descriptor:	BLOOD COAGULATION FACTOR VIIA heavy chain, BLOOD COAGULATION FACTOR VIIA light chain, CACODYLATE ION, ...
Authors:	Banner, D.W.
Deposit date:	1997-03-05
Release date:	1997-09-04
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature, 380, 1996

1DDX

CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[6-(3-HYDROPEROXY-OCT-1-ENYL)-2,3-DIOXA-BICYCLO[2.2.1]HEPT-5-YL]-HEPT-5-ENOIC ACID, ...
Authors:	Kiefer, J.R, Pawlitz, J.L, Moreland, K.T, Stegeman, R.A, Gierse, J.K, Stevens, A.M, Goodwin, D.C, Rowlinson, S.W, Marnett, L.J, Stallings, W.C, Kurumbail, R.G.
Deposit date:	1999-11-11
Release date:	2000-05-16
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature, 405, 2000

4CC0

Notch ligand, Jagged-1, contains an N-terminal C2 domain
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PROTEIN JAGGED-1, ...
Authors:	Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M.
Deposit date:	2013-10-17
Release date:	2013-11-27
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013

4BXS

Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:	Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:	2013-07-15
Release date:	2013-07-31
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (3.32 Å)
Cite:	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013

4BTI

factor Xa in complex with the dual thrombin-FXa inhibitor 58.
Descriptor:	5-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-difluoromethoxy-3-(2-oxo-piperidin-1-yl)-benzenesulfonylamino]-3-((S)-3-dimethylamino-pyrrolidin-1-yl)-3-oxo-propyl]-amide, CALCIUM ION, COAGULATION FACTOR X HEAVY CHAIN, ...
Authors:	Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M.
Deposit date:	2013-06-18
Release date:	2013-12-25
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem., 56, 2013

4BTT

factor Xa in complex with the dual thrombin-FXa inhibitor 31.
Descriptor:	CALCIUM ION, COAGULATION FACTOR X, COAGULATION FACTOR X LIGHT CHAIN, ...
Authors:	Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M.
Deposit date:	2013-06-19
Release date:	2013-12-18
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem., 56, 2013

1DVA

Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
Descriptor:	CACODYLATE ION, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ...
Authors:	Eigenbrot, C, Ultsch, M.H.
Deposit date:	2000-01-20
Release date:	2000-05-12
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Peptide exosite inhibitors of factor VIIa as anticoagulants. Nature, 404, 2000

4BXW

Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor:	COAGULATION FACTOR V, FACTOR XA, GLYCEROL, ...
Authors:	Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:	2013-07-16
Release date:	2013-07-31
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.71 Å)
Cite:	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013

4CUF

Human Notch1 EGF domains 11-13 mutant T466S
Descriptor:	1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:	Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:	2014-03-18
Release date:	2014-05-14
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111, 2014

4COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, INDOMETHACIN, ...
Authors:	Kurumbail, R, Stallings, W.
Deposit date:	1996-12-18
Release date:	1997-12-24
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996

1ESL

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
Descriptor:	CALCIUM ION, CHLORIDE ION, HUMAN E-SELECTIN
Authors:	Graves, B.J, Crowther, R.L.
Deposit date:	1994-06-03
Release date:	1994-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature, 367, 1994

1F0R

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815
Descriptor:	CALCIUM ION, COAGULATION FACTOR XA, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
Authors:	Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:	2000-05-17
Release date:	2000-09-20
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000

1EZQ

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515
Descriptor:	3-[(3'-AMINOMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-2-(3-CARBAMIMIDOYL-BENZYL)-BUTYRIC ACID METHYL ESTER, CALCIUM ION, COAGULATION FACTOR XA
Authors:	Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V.
Deposit date:	2000-05-11
Release date:	2000-09-20
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000

1IQG

Human coagulation factor Xa in complex with M55159
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQN

Human coagulation factor Xa in complex with M55192
Descriptor:	4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IVO

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal Growth Factor Receptor, ...
Authors:	Ogiso, H, Ishitani, R, Nureki, O, Fukai, S, Yamanaka, M, Kim, J.H, Saito, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2002-03-28
Release date:	2002-10-16
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. Cell(Cambridge,Mass.), 110, 2002

1IQH

Human coagulation factor Xa in complex with M55143
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQK

Human coagulation factor Xa in complex with M55113
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQI

Human coagulation factor Xa in complex with M55125
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL] METHYL]-2-PIPERAZINECARBOXYLIC ACID, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1J9C

Crystal Structure of tissue factor-factor VIIa complex
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ...
Authors:	Huang, M, Ruf, W, Edgington, T.S, Wilson, I.A.
Deposit date:	2001-05-24
Release date:	2004-07-27
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Ligand Induced Conformational Transitions of Tissue Factor. Crystal Structure of the Tissue Factor:Factor VIIa Complex. To be Published

1KSN

Crystal Structure of Human Coagulation Factor XA Complexed with FXV673
Descriptor:	CALCIUM ION, COAGULATION FACTOR XA, METHYL-3-(4'-N-OXOPYRIDYLPHENOYL)-3-METHYL-2-(M-AMIDINOBENZYL)-PROPIONATE
Authors:	Maignan, S, Guilloteau, J.P.
Deposit date:	2002-01-14
Release date:	2002-06-19
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity. Bioorg.Med.Chem.Lett., 12, 2002

1IQJ

Human coagulation factor Xa in complex with M55124
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQE

Human coagulation factor Xa in complex with M55590
Descriptor:	4-[(2R)-3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-1-OXO-2-[[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]AMINO]PROPYL]-THIOMORPHOLINE-1,1-DIOXIDE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQM

Human coagulation factor Xa in complex with M54471
Descriptor:	1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1LPK

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.
Descriptor:	1-(3-CARBAMIMIDOYL-BENZYL)-1H-INDOLE-2-CARBOXYLIC ACID 3-CARBAMIMIDOYL-BENZYLESTER, Blood coagulation factor Xa, CALCIUM ION
Authors:	Schreuder, H.A, Loenze, P, Brachvogel, V, Liesum, A.
Deposit date:	2002-05-08
Release date:	2003-05-08
Last modified:	2021-10-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa J.Med.Chem., 45, 2002

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Total results:	282
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	PF00008