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1IAR
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BU of 1iar by Molmil
INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
Descriptor: PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN), PROTEIN (INTERLEUKIN-4)
Authors:Hage, T, Sebald, W, Reinemer, P.
Deposit date:1999-02-25
Release date:2000-03-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
1UO4
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BU of 1uo4 by Molmil
Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles
Descriptor: CHLORIDE ION, GENERAL CONTROL PROTEIN GCN4, iodobenzene
Authors:Yadav, M.K, Redman, J.E, Alvarez-Gutierrez, J.M, Zhang, Y, Stout, C.D, Ghadiri, M.R.
Deposit date:2003-09-15
Release date:2004-10-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides
Biochemistry, 44, 2005
4RUJ
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BU of 4ruj by Molmil
Crystal structure of zVDR L337H mutant-VD complex
Descriptor: 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, Nuclear receptor coactivator 1, Vitamin D3 receptor A
Authors:Huet, T, Moras, D, Rochel, N.
Deposit date:2014-11-20
Release date:2015-10-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Cell Rep, 10, 2015
4S2Z
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BU of 4s2z by Molmil
ERK2 Intrinsically active mutant R65S
Descriptor: Mitogen-activated protein kinase 1
Authors:Livnah, O, Karamansha, Y.
Deposit date:2015-01-25
Release date:2016-01-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Multiple mechanisms render Erk proteins MEK-independent
To be Published
1HIJ
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BU of 1hij by Molmil
INTERLEUKIN-4 MUTANT WITH ARG 88 REPLACED WITH GLN (R88Q)
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
1PP8
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BU of 1pp8 by Molmil
crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element
Descriptor: 39 kDa initiator binding protein, ALPHA-SCS INR, SULFATE ION
Authors:Schumacher, M.A, Lau, A.O.T, Johnson, P.J.
Deposit date:2003-06-16
Release date:2003-11-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural Basis of Core Promoter Recognition in a Primitive Eukaryote
Cell(Cambridge,Mass.), 115, 2003
1HIK
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BU of 1hik by Molmil
INTERLEUKIN-4 (WILD-TYPE)
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
2COB
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BU of 2cob by Molmil
Solution structures of the HTH domain of human LCoR protein
Descriptor: LCoR protein
Authors:Nameki, N, Umehara, T, Sato, M, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-17
Release date:2005-11-17
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structures of the HTH domain of human LCoR protein
To be Published
1ESX
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BU of 1esx by Molmil
1H, 15N AND 13C STRUCTURE OF THE HIV-1 REGULATORY PROTEIN VPR : COMPARISON WITH THE N-AND C-TERMINAL DOMAIN STRUCTURE, (1-51)VPR AND (52-96)VPR
Descriptor: VPR PROTEIN
Authors:Wecker, K, Morellet, N, Bouaziz, S, Roques, B.
Deposit date:2000-04-11
Release date:2001-04-11
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains.
Eur.J.Biochem., 269, 2002
1HZI
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BU of 1hzi by Molmil
INTERLEUKIN-4 MUTANT E9A
Descriptor: INTERLEUKIN-4, SULFATE ION
Authors:Hulsmeyer, M, Scheufler, C, Dreyer, M.K.
Deposit date:2001-01-25
Release date:2001-08-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.
Acta Crystallogr.,Sect.D, 57, 2001
2LGC
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BU of 2lgc by Molmil
Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution
Descriptor: Mitogen-activated protein kinase 14
Authors:Habeck, M.
Deposit date:2011-07-25
Release date:2012-07-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38alpha MAP kinase complex in solution
Angew.Chem.Int.Ed.Engl., 51, 2012
2JWO
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BU of 2jwo by Molmil
A PHD finger motif in the C-terminus of RAG2 modulates recombination activity
Descriptor: V(D)J recombination-activating protein 2, ZINC ION
Authors:Ivanov, D, Hyberts, S.G, Sun, Z, Wagner, G.
Deposit date:2007-10-17
Release date:2007-11-06
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
J.Biol.Chem., 280, 2005
7KKQ
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BU of 7kkq by Molmil
Structure of the catalytic domain of tankyrase 1 in complex with veliparib
Descriptor: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase, ZINC ION
Authors:Gajiwala, K.S, Ryan, K.
Deposit date:2020-10-27
Release date:2021-01-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
J.Biol.Chem., 296, 2021
4WF9
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BU of 4wf9 by Molmil
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with telithromycin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eyal, Z, Matzov, D, Krupkin, M, Wekselman, I, Zimmerman, E, Rozenberg, H, Bashan, A, Yonath, A.E.
Deposit date:2014-09-14
Release date:2015-10-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.427 Å)
Cite:Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 112, 2015
7ZUB
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BU of 7zub by Molmil
Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
Descriptor: (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one, ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, ...
Authors:Gruszczyk, J, Savva, C.G, Lai-Kee-Him, J, Bous, J, Ancelin, A, Kwong, H.S, Grandvuillemin, L, Bourguet, W.
Deposit date:2022-05-12
Release date:2022-11-23
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Nat Commun, 13, 2022
4WJV
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BU of 4wjv by Molmil
Crystal structure of Rsa4 in complex with the Nsa2 binding peptide
Descriptor: Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ...
Authors:Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I.
Deposit date:2014-10-01
Release date:2014-11-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
4WQK
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BU of 4wqk by Molmil
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, apo form
Descriptor: 2''-aminoglycoside nucleotidyltransferase, CHLORIDE ION, GLYCEROL, ...
Authors:Cox, G, Stogios, P.J, Savchenko, A, Wright, G.D, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-10-22
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.482 Å)
Cite:Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio, 6, 2015
4WTH
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BU of 4wth by Molmil
Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic)
Descriptor: Maltose-binding periplasmic protein, Ataxin-3 chimera, ZINC ION, ...
Authors:Zhemkov, V.A, Kim, M.
Deposit date:2014-10-30
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
FEBS Open Bio, 6, 2016
3VA2
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BU of 3va2 by Molmil
Crystal structure of human Interleukin-5 in complex with its alpha receptor
Descriptor: Interleukin-5, Interleukin-5 receptor subunit alpha
Authors:Kusano, S, Kukimoto-Niino, M, Shirouzu, M, Yokoyama, S.
Deposit date:2011-12-28
Release date:2012-07-25
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Structural basis of interleukin-5 dimer recognition by its alpha receptor
Protein Sci., 21, 2012
7KRE
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BU of 7kre by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((6-cyanonaphthalen-1-yl)oxy)-3-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenyl sulfurofluoridate (JLJ704)
Descriptor: 4-[(6-cyanonaphthalen-1-yl)oxy]-3-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenyl sulfurofluoridate, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ...
Authors:Bertoletti, N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S.
Deposit date:2020-11-19
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.728 Å)
Cite:Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.
Acs Med.Chem.Lett., 12, 2021
7KKP
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BU of 7kkp by Molmil
Structure of the catalytic domain of tankyrase 1 in complex with niraparib
Descriptor: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, Poly [ADP-ribose] polymerase, SULFATE ION, ...
Authors:Gajiwala, K.S, Ryan, K.
Deposit date:2020-10-27
Release date:2021-01-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
J.Biol.Chem., 296, 2021
4WMW
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BU of 4wmw by Molmil
The structure of MBP-MCL1 bound to ligand 5 at 1.9A
Descriptor: 1,2-ETHANEDIOL, 2-hydroxy-5-(methylsulfanyl)benzoic acid, FORMIC ACID, ...
Authors:Clifton, M.C, Dranow, D.M.
Deposit date:2014-10-09
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WQL
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BU of 4wql by Molmil
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, kanamycin-bound
Descriptor: 2''-aminoglycoside nucleotidyltransferase, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Cox, G, Stogios, P.J, Savchenko, A, Wright, G.D, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-10-22
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio, 6, 2015
4WVI
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BU of 4wvi by Molmil
Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep2).
Descriptor: Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, substrate peptide (pep2)
Authors:Young, P.G, Ting, Y.T, Baker, E.N.
Deposit date:2014-11-05
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization.
IUCrJ, 3, 2016
4WVF
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BU of 4wvf by Molmil
Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Descriptor: (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Sun, Q, Chook, Y.
Deposit date:2014-11-05
Release date:2015-07-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015

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数据于2024-10-16公开中

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