4WQL

Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, kanamycin-bound

Summary for 4WQL

• Entry DOI: 10.2210/pdb4wql/pdb
• Related: 4WQK
• Descriptor: 2''-aminoglycoside nucleotidyltransferase, MAGNESIUM ION, KANAMYCIN A, ... (6 entities in total)
• Functional Keywords: antibiotic resistance, aminoglycosides, kanamycin, nucleotidylyltransferase, adenylyltransferase, nucleotidyltransferase fold, alpha/beta protein, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 21212.47

Authors

Cox, G.,Stogios, P.J.,Savchenko, A.,Wright, G.D.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2014-10-22, release date: 2014-11-12, Last modification date: 2023-12-27)

• Primary citation: Cox, G.,Stogios, P.J.,Savchenko, A.,Wright, G.D.; Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.; Mbio, 6:-, 2015; PubMed: 25564464; DOI: 10.1128/mBio.02180-14

Experimental method

X-RAY DIFFRACTION (1.73 Å)