4WQL
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, kanamycin-bound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | ASP44 |
| A | ASP46 |
| A | MG202 |
| A | HOH491 |
| A | HOH492 |
| A | HOH495 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | MG201 |
| A | KAN203 |
| A | ASP44 |
| A | ASP46 |
| A | ASP86 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue KAN A 203 |
| Chain | Residue |
| A | ASP44 |
| A | ASP46 |
| A | TYR74 |
| A | ASP86 |
| A | GLU88 |
| A | ILE99 |
| A | ALA100 |
| A | ASP131 |
| A | TYR134 |
| A | GLU138 |
| A | MG202 |
| A | GOL213 |
| A | HOH421 |
| A | HOH426 |
| A | HOH478 |
| A | HOH529 |
| A | HOH534 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue IPA A 204 |
| Chain | Residue |
| A | GLY28 |
| A | ARG40 |
| A | HIS42 |
| A | ASP43 |
| A | HOH491 |
| A | HOH508 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue IPA A 205 |
| Chain | Residue |
| A | GLU109 |
| A | HOH316 |
| A | HOH493 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue IPA A 206 |
| Chain | Residue |
| A | PHE133 |
| A | TYR152 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue IPA A 209 |
| Chain | Residue |
| A | GLU95 |
| A | GLU109 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 210 |
| Chain | Residue |
| A | VAL166 |
| A | HOH355 |
| A | HOH418 |
| A | HOH440 |
| A | HOH506 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 211 |
| Chain | Residue |
| A | GLU52 |
| A | TRP91 |
| A | HOH513 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 212 |
| Chain | Residue |
| A | GLU79 |
| A | GLY81 |
| A | ASP82 |
| A | HOH343 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue GOL A 213 |
| Chain | Residue |
| A | GLY26 |
| A | GLY27 |
| A | GLU88 |
| A | ILE99 |
| A | ASN123 |
| A | ILE128 |
| A | ASP131 |
| A | KAN203 |
| A | HOH417 |
| A | HOH419 |
| A | HOH446 |
| A | HOH526 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Region: {"description":"C-terminal domain","evidences":[{"source":"PubMed","id":"25564464","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28734024","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"25564464","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25564464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25564464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
