PDB: 2832 resultsInfo pagesStatus searchChemie searchBIRD

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7DGQ	Activity optimized supercomplex state1 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. Deposit date: 2020-11-12 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (5 Å) Cite: A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
7DGZ	Activity optimized complex I (closed form) Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. Deposit date: 2020-11-12 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
7DKF	Activity optimized supercomplex state4 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. Deposit date: 2020-11-24 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (8.3 Å) Cite: A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
7DH0	Activity optimized complex I (open form) Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. Deposit date: 2020-11-12 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
7DGS	Activity optimized supercomplex state3 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. Deposit date: 2020-11-12 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (7.8 Å) Cite: A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase Authors: Schumacher, B, Weyand, M, Ottmann, C. Deposit date: 2010-06-21 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
7B93	Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-5-[3-[4-(trifluoromethyloxy)phenyl]-1,2,4-oxadiazol-5-yl]pyridin-2-one, ... Authors: Chung, I, Hirst, J. Deposit date: 2020-12-14 Release date: 2021-05-26 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Cork-in-bottle mechanism of inhibitor binding to mammalian complex I. Sci Adv, 7, 2021
3PUP	Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1) Descriptor: Glycogen synthase kinase-3 beta, Ruthenium octasporine Authors: Filippakopoulos, P, Kraling, K, Essen, L.O, Meggers, E, Knapp, S. Deposit date: 2010-12-06 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J.Am.Chem.Soc., 133, 2011
3Q3B	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors Descriptor: 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one, Glycogen synthase kinase-3 beta Authors: Pandit, J. Deposit date: 2010-12-21 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors Bioorg.Med.Chem.Lett., 21, 2011
7DCO	Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom Descriptor: BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... Authors: Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. Deposit date: 2020-10-26 Release date: 2021-03-17 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
3L1S	3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3 Descriptor: (4E)-4-[(4-chlorophenyl)hydrazono]-5-(3,4-dimethoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION Authors: Haar, T.E. Deposit date: 2009-12-14 Release date: 2010-03-02 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: 3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta. Bioorg.Med.Chem.Lett., 20, 2010
3M1S	Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 Descriptor: Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole Authors: Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. Deposit date: 2010-03-05 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.134 Å) Cite: Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta J.Biol.Inorg.Chem., 16, 2011
7ZIT	14-3-3 in complex with SARS-COV2 N phospho-peptide Descriptor: 14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ... Authors: Eisenreichova, A, Boura, E. Deposit date: 2022-04-08 Release date: 2022-10-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins. J.Struct.Biol., 214, 2022
3RDH	X-ray induced covalent inhibition of 14-3-3 Descriptor: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION Authors: Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. Deposit date: 2011-04-01 Release date: 2011-09-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
6ND4	Conformational switches control early maturation of the eukaryotic small ribosomal subunit Descriptor: 18S rRNA 5' domain start, 5'ETS rRNA, Bud21, ... Authors: Hunziker, M, Barandun, J, Klinge, S. Deposit date: 2018-12-13 Release date: 2019-06-19 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Conformational switches control early maturation of the eukaryotic small ribosomal subunit. Elife, 8, 2019
4BBQ	Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11) Descriptor: 1,2-ETHANEDIOL, LYSINE-SPECIFIC DEMETHYLASE 2A, ZINC ION Authors: Allerston, C.K, Watson, A.A, Edlich, C, Li, B, Chen, Y, Ball, L, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Laue, E.D, Gileadi, O. Deposit date: 2012-09-27 Release date: 2012-10-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Crystal Structure of the Cxxc and Phd Domain of Human Lysine-Specific Demethylase 2A (Kdm2A)(Fbxl11) To be Published
6KL7	Beta-arrestin 1 mutant S13D/T275D Descriptor: 1,2-ETHANEDIOL, BARIUM ION, Beta-arrestin-1 Authors: Kang, H, Choi, H.J. Deposit date: 2019-07-29 Release date: 2020-01-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.794 Å) Cite: Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins. Structure, 28, 2020
7Z38	Structure of the RAF1-HSP90-CDC37 complex (RHC-I) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... Authors: Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. Deposit date: 2022-03-01 Release date: 2022-09-14 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
7Z37	Structure of the RAF1-HSP90-CDC37 complex (RHC-II) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... Authors: Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. Deposit date: 2022-03-01 Release date: 2022-09-14 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
8Q49	Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-05 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q0A	Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-07-28 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q0O	Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-07-28 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q46	Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-05 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q4A	Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-08-05 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024
8Q0J	Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Grba, D.N, Hirst, J. Deposit date: 2023-07-28 Release date: 2024-06-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science, 384, 2024

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