3PUP

Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)

Summary for 3PUP

Entry DOI	10.2210/pdb3pup/pdb
Descriptor	Glycogen synthase kinase-3 beta, Ruthenium octasporine (2 entities in total)
Functional Keywords	wnt signaling pathway, serine/threonine-protein kinase, ruthenium glycogen synthase kinase picomolar, nucleotide-binding, kinase, transferase, atp-binding, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P49841
Total number of polymer chains	2
Total formula weight	94748.32
Authors	Filippakopoulos, P.,Kraling, K.,Essen, L.O.,Meggers, E.,Knapp, S. (deposition date: 2010-12-06, release date: 2010-12-22, Last modification date: 2023-09-06)
Primary citation	Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.O.,Meggers, E. Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J.Am.Chem.Soc., 133:5976-5986, 2011 Cited by PubMed: 21446733 DOI: 10.1021/ja1112996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation