PDB: 292 resultsInfo pagesStatus searchChemie searchBIRD

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5VQI	Nuclear transport of the Neurospora crassa NIT2 transcription factor is mediated by Importin-alpha Descriptor: Importin subunit alpha, Nuclear localization sequence of NIT2 transcription factor (NIT2-NLS) Authors: Bernardes, N.E, Fontes, M.R.M. Deposit date: 2017-05-09 Release date: 2017-11-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha. Biochem. J., 474, 2017
5W4F	Importin binding to pol Mu NLS peptide Descriptor: DNA-directed DNA/RNA polymerase mu, GLYCEROL, Importin subunit alpha-1 Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-06-10 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.984 Å) Cite: Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
5UMZ	Structure of TNRC6A NLS in complex with importin-alpha Descriptor: GLYCEROL, Importin subunit alpha-1, TNRC6A Authors: Chaston, J, Stewart, A.G, Christie, M. Deposit date: 2017-01-30 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE, 12, 2017
5V5O	Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
8TUT	Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 Descriptor: Importin subunit alpha-1, PRO-PRO-LYS-PRO-LYS-LYS-ASN-ARG-GLU Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8Q8K	KI Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-18 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
5U5R	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Mismatch repair endonuclease PMS2 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5W41	Zika MR766 NLS in complex with Importin alpha subunit-1 Descriptor: Importin subunit alpha-1, ZIKA MR766 NLS Authors: Jeffress, S, Smith, K.M, Forwood, J.K. Deposit date: 2017-06-08 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells. ACS Infect Dis, 2019
8TUS	WU Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUU	MW Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T-antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUR	Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Truncated large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUQ	STL Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8SV0	The crystal structure of the classical binding interface of Importin alpha 2 and nuclear localisation signal sequence in Psittacine siadenovirus core protein VII Descriptor: Importin subunit alpha-1, SODIUM ION, protein VII Authors: Athukorala, A, Sarker, S, Forwood, J.K, Donnelly, C.M. Deposit date: 2023-05-14 Release date: 2023-05-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and functional characterization of nuclear localization signal of pVII protein of psittacine siadenovirus F demonstrates an independent transport of pVII protein into the nucleus To Be Published
5W4E	Importin binding to Tdt NLS peptide Descriptor: GLYCEROL, Importin subunit alpha-1,Importin subunit alpha-1, human DNA repair polymerase Tdt Authors: Pedersen, L.C, London, R. Deposit date: 2017-06-10 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
8SG7	Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2 Descriptor: Importin subunit alpha-1, VP1 capsid Authors: Hoad, M, Forwood, J.K. Deposit date: 2023-04-11 Release date: 2023-07-19 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for nuclear import of bat adeno-associated virus capsid protein. J.Gen.Virol., 105, 2024
5U5P	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.171 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5W4G	Importin binding to NLS peptide of DNA polymerase lambda Descriptor: DNA polymerase lambda, GLYCEROL, Importin subunit alpha-1, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-06-10 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.038 Å) Cite: Structure of Importin with bound NLS from DNA polymerase lambda To Be Published
5WUN	Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1 Descriptor: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1 Authors: Nakada, R, Hirano, H, Matsuura, Y. Deposit date: 2016-12-19 Release date: 2017-01-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal. Biochem. Biophys. Res. Commun., 484, 2017
5WUM	Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1 Descriptor: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1 Authors: Nakada, R, Hirano, H, Matsuura, Y. Deposit date: 2016-12-19 Release date: 2017-01-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal. Biochem. Biophys. Res. Commun., 484, 2017
4BPL	rice importin_alpha in complex with nucleoplasmin NLS Descriptor: IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS Authors: Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. Deposit date: 2013-05-27 Release date: 2014-02-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium Vird2 with Rice Importin-Alpha Mol.Plant, 7, 2014
4B8O	rImp_alpha_SV40TAgNLS Descriptor: IMPORTIN SUBUNIT ALPHA-1A, SV40TAGNLS Authors: Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. Deposit date: 2012-08-28 Release date: 2013-01-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.084 Å) Cite: Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals. Plant Cell, 24, 2012
4B8J	rImp_alpha1a Descriptor: IMPORTIN SUBUNIT ALPHA-1A Authors: Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. Deposit date: 2012-08-28 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals. Plant Cell, 24, 2012
4B8P	rImp_alpha_A89NLS Descriptor: A89NLS, IMPORTIN SUBUNIT ALPHA-1A Authors: Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. Deposit date: 2012-08-29 Release date: 2013-01-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals. Plant Cell, 24, 2012
4B18	The crystal structure of human Importin alpha 5 with TERT NLS peptide Descriptor: IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE TRANSCRIPTASE Authors: Kim, K.L, Yoo, J.H, Cho, H.S. Deposit date: 2012-07-08 Release date: 2013-09-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation. J.Cell.Sci., 128, 2015

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