8ERA
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![BU of 8era by Molmil](/molmil-images/mine/8era) | RMC-5552 in complex with mTORC1 and FKBP12 | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Tomlinson, A.C.A, Yano, J.K. | Deposit date: | 2022-10-11 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
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7UX2
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6U62
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![BU of 6u62 by Molmil](/molmil-images/mine/6u62) | Raptor-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Rogala, K.B, Sabatini, D.M. | Deposit date: | 2019-08-29 | Release date: | 2019-10-30 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
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7UXH
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![BU of 7uxh by Molmil](/molmil-images/mine/7uxh) | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Cui, Z, Hurley, J. | Deposit date: | 2022-05-05 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
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7UXC
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6BCX
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![BU of 6bcx by Molmil](/molmil-images/mine/6bcx) | mTORC1 structure refined to 3.0 angstroms | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2017-10-20 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
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7PEB
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6BCU
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7PEA
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![BU of 7pea by Molmil](/molmil-images/mine/7pea) | |
7PEC
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![BU of 7pec by Molmil](/molmil-images/mine/7pec) | |
5H64
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![BU of 5h64 by Molmil](/molmil-images/mine/5h64) | Cryo-EM structure of mTORC1 | Descriptor: | Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | Authors: | Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H. | Deposit date: | 2016-11-10 | Release date: | 2017-01-25 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1 Protein Cell, 7, 2016
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7OWG
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![BU of 7owg by Molmil](/molmil-images/mine/7owg) | human DEPTOR in a complex with mutant human mTORC1 A1459P | Descriptor: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | Authors: | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
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6SB0
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![BU of 6sb0 by Molmil](/molmil-images/mine/6sb0) | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6SB2
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![BU of 6sb2 by Molmil](/molmil-images/mine/6sb2) | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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