4V9K
 
 | | 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state. | | Descriptor: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | | Deposit date: | 2013-04-24 | | Release date: | 2014-07-09 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
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2RDO
 | | 50S subunit with EF-G(GDPNP) and RRF bound | | Descriptor: | 23S RIBOSOMAL RNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ... | | Authors: | Gao, N, Zavialov, A.V, Ehrenberg, M, Frank, J. | | Deposit date: | 2007-09-24 | | Release date: | 2008-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits.
J.Mol.Biol., 374, 2007
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7DCO
 | | Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom | | Descriptor: | BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... | | Authors: | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | | Deposit date: | 2020-10-26 | | Release date: | 2021-03-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
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1U2R
 | | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Elongation factor 2, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Jorgensen, R, Yates, S.P, Nilsson, J, Prentice, G.A, Teal, D.J, Merrill, A.R, Andersen, G.R. | | Deposit date: | 2004-07-20 | | Release date: | 2004-09-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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1N0V
 | | Crystal structure of elongation factor 2 | | Descriptor: | Elongation factor 2 | | Authors: | Joergensen, R, Ortiz, P.A, Carr-Schmid, A, Nissen, P, Kinzy, T.G, Andersen, G.R. | | Deposit date: | 2002-10-15 | | Release date: | 2002-11-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase.
Nat.Struct.Biol., 10, 2003
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2J7K
 | | Crystal structure of the T84A mutant EF-G:GDPCP complex | | Descriptor: | ELONGATION FACTOR G, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | | Authors: | Hansson, S, Logan, D.T. | | Deposit date: | 2006-10-12 | | Release date: | 2007-10-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | New Insights Into the Role of the P-Loop Lysine: Implications from the Crystal Structure of a Mutant EF-G:Gdpcp Complex
To be Published
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8BSI
 | | Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1) | | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | | Deposit date: | 2022-11-25 | | Release date: | 2023-03-15 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Nucleic Acids Res., 51, 2023
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2XEX
 | | crystal structure of Staphylococcus aureus elongation factor G | | Descriptor: | CHLORIDE ION, ELONGATION FACTOR G, POTASSIUM ION | | Authors: | Chen, Y, Koripella, R.K, Sanyal, S, Selmer, M. | | Deposit date: | 2010-05-19 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Staphylococcus Aureus Elongation Factor G - Structure and Analysis of a Target for Fusidic Acid.
FEBS J., 277, 2010
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3DNY
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7DVQ
 | | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | | Deposit date: | 2021-01-14 | | Release date: | 2021-03-31 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure of the activated human minor spliceosome.
Science, 371, 2021
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4FN5
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1ELO
 | | ELONGATION FACTOR G WITHOUT NUCLEOTIDE | | Descriptor: | ELONGATION FACTOR G | | Authors: | Aevarsson, A, Brazhnikov, E, Garber, M, Zheltonosova, J, Chirgadze, Yu, Al-Karadaghi, S, Svensson, L.A, Liljas, A. | | Deposit date: | 1996-03-13 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus.
EMBO J., 13, 1994
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7N2C
 | | Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-28 | | Release date: | 2021-07-14 | | Last modified: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2V
 | | Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-29 | | Release date: | 2021-07-14 | | Last modified: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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1FNM
 | | STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A | | Descriptor: | ELONGATION FACTOR G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Laurberg, M, Kristensen, O, Martemyanov, K, Gudkov, A.T, Nagaev, I, Hughes, D, Liljas, A. | | Deposit date: | 2000-08-22 | | Release date: | 2000-11-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.
J.Mol.Biol., 303, 2000
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5O9Z
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6NOT
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1KTV
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1JQM
 | | Fitting of L11 protein and elongation factor G (EF-G) in the cryo-em map of e. coli 70S ribosome bound with EF-G, GDP and fusidic acid | | Descriptor: | 50S Ribosomal protein L11, Elongation Factor G | | Authors: | Agrawal, R.K, Linde, J, Segupta, J, Nierhaus, K.H, Frank, J. | | Deposit date: | 2001-08-07 | | Release date: | 2001-09-07 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (18 Å) | | Cite: | Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation.
J.Mol.Biol., 311, 2001
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6N0I
 | | 2.60 Angstrom Resolution Crystal Structure of Elongation Factor G 2 from Pseudomonas putida. | | Descriptor: | DI(HYDROXYETHYL)ETHER, Elongation factor G 2, SULFATE ION | | Authors: | Minasov, G, Shuvalova, L, Wawrzak, Z, Cardona-Correa, A, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-11-07 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | 2.60 Angstrom Resolution Crystal Structure of Elongation Factor G 2 from Pseudomonas putida.
To Be Published
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6VMI
 | | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII) | | Descriptor: | 12s rRNA, 16s rRNA, 28S ribosomal protein S10, ... | | Authors: | Sharma, M.R, Koripella, R.K, Agrawal, R.K. | | Deposit date: | 2020-01-28 | | Release date: | 2020-08-05 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
Nat Commun, 11, 2020
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6VLZ
 | | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI) | | Descriptor: | 12s rRNA, 16s rRNA, 28S ribosomal protein S10, ... | | Authors: | Sharma, M.R, Koripella, R.K, Agrawal, R.K. | | Deposit date: | 2020-01-27 | | Release date: | 2020-08-05 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
Nat Commun, 11, 2020
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7UG7
 | | 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N. | | Deposit date: | 2022-03-24 | | Release date: | 2022-05-18 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1N0U
 | | Crystal structure of yeast elongation factor 2 in complex with sordarin | | Descriptor: | Elongation factor 2, [1R-(1.ALPHA.,3A.BETA.,4.BETA.,4A.BETA.,7.BETA.,7A.ALPHA.,8A.BETA.)]8A-[(6-DEOXY-4-O-METHYL-BETA-D-ALTROPYRANOSYLOXY)METHYL]-4-FORMYL-4,4A,5,6,7,7A,8,8A-OCTAHYDRO-7-METHYL-3-(1-METHYLETHYL)-1,4-METHANO-S-INDACENE-3A(1H)-CARBOXYLIC ACID | | Authors: | Joergensen, R, Ortiz, P.A, Carr-Schmid, A, Nissen, P, Kinzy, T.G, Andersen, G.R. | | Deposit date: | 2002-10-15 | | Release date: | 2003-02-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase.
Nat. Struct. Biol., 10, 2003
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7UVP
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