3IX3
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![BU of 3ix3 by Molmil](/molmil-images/mine/3ix3) | LasR-OC12 HSL complex | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | LasR-OC12 HSL complex TO BE PUBLISHED
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6MWL
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![BU of 6mwl by Molmil](/molmil-images/mine/6mwl) | LasR LBD:mBTL complex | Descriptor: | 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-29 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
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6D6L
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![BU of 6d6l by Molmil](/molmil-images/mine/6d6l) | |
6D6O
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![BU of 6d6o by Molmil](/molmil-images/mine/6d6o) | |
6D6P
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![BU of 6d6p by Molmil](/molmil-images/mine/6d6p) | |
6MWZ
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![BU of 6mwz by Molmil](/molmil-images/mine/6mwz) | LasR LBD T75V/Y93F/A127W:BB0126 | Descriptor: | 4-[3-(methylsulfonyl)phenoxy]-N-[(1S,3S,5S)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, ALA-HIS-HIS-HIS-HIS-ALA, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.657 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
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6D6D
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![BU of 6d6d by Molmil](/molmil-images/mine/6d6d) | |
6D6B
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![BU of 6d6b by Molmil](/molmil-images/mine/6d6b) | |
2UV0
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![BU of 2uv0 by Molmil](/molmil-images/mine/2uv0) | Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR | Authors: | Bottomley, M.J, Muraglia, E, Bazzo, R, Carfi, A. | Deposit date: | 2007-03-08 | Release date: | 2007-03-27 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer. J.Biol.Chem., 282, 2007
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3IX4
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![BU of 3ix4 by Molmil](/molmil-images/mine/3ix4) | LasR-TP1 complex | Descriptor: | 2,4-dibromo-6-({[(2-nitrophenyl)carbonyl]amino}methyl)phenyl 2-chlorobenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
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3IX8
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![BU of 3ix8 by Molmil](/molmil-images/mine/3ix8) | LasR-TP3 complex | Descriptor: | 2,4-dibromo-6-({[(2-chlorophenyl)carbonyl]amino}methyl)phenyl 2-methylbenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-03 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
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6D6N
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![BU of 6d6n by Molmil](/molmil-images/mine/6d6n) | The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 16 | Descriptor: | 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-methoxybenzoate, PHENYLALANINE, Transcriptional activator protein LasR | Authors: | Dong, S.H, Nair, S.K. | Deposit date: | 2018-04-21 | Release date: | 2018-08-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
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6D6C
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![BU of 6d6c by Molmil](/molmil-images/mine/6d6c) | |
6D6A
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![BU of 6d6a by Molmil](/molmil-images/mine/6d6a) | |
6D6M
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![BU of 6d6m by Molmil](/molmil-images/mine/6d6m) | |
6MWH
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![BU of 6mwh by Molmil](/molmil-images/mine/6mwh) | LasR LBD:BB0020 complex | Descriptor: | 2-(3-bromophenoxy)-N-[(1S,2S,3R,5S)-2-hydroxybicyclo[3.1.0]hexan-3-yl]acetamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-29 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
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3JPU
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![BU of 3jpu by Molmil](/molmil-images/mine/3jpu) | LasR-TP4 complex | Descriptor: | 4-bromo-2-({[(2-chlorophenyl)carbonyl]amino}methyl)-6-methylphenyl 2,4-dichlorobenzoate, Transcriptional activator protein lasR | Authors: | Zou, Y, Nair, S.K. | Deposit date: | 2009-09-04 | Release date: | 2009-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
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4NG2
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![BU of 4ng2 by Molmil](/molmil-images/mine/4ng2) | |
6MWW
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![BU of 6mww by Molmil](/molmil-images/mine/6mww) | LasR LBD:BB0126 complex | Descriptor: | 4-[3-(methylsulfonyl)phenoxy]-N-[(1R,3R,5R)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, Transcriptional regulator LasR | Authors: | Bassler, B.L, Paczkowski, J.E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. Acs Chem.Biol., 14, 2019
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6V7X
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![BU of 6v7x by Molmil](/molmil-images/mine/6v7x) | Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR | Descriptor: | N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, QUORUM SENSING ANTI-ACTIVATOR PROTEIN AQS1, Transcriptional regulator LasR | Authors: | Shah, M, Moraes, T.F, Maxwell, K.L. | Deposit date: | 2019-12-09 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol.Cell, 81, 2021
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6V7W
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![BU of 6v7w by Molmil](/molmil-images/mine/6v7w) | |