3ZE1
 
 | | Integrin alphaIIB beta3 headpiece and RGD peptide complex | | Descriptor: | 10E5 FAB HEAVY CHAIN, 10E5 FAB LIGHT CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhu, J.H, Zhu, J.Q, Springer, T.A. | | Deposit date: | 2012-12-03 | | Release date: | 2013-06-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Complete Integrin Headpiece Opening in Eight Steps.
J.Cell Biol., 201, 2013
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8T2U
 | | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | Deposit date: | 2023-06-06 | | Release date: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
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2VC2
 | | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 | | Descriptor: | 2-(S)-[N-(3-PYRIDYLSULFONYL)AMINO]-3-[[2-CARBONYL-5-[2-(PIPERIDIN-4-YL)ETHYL]-THIENO[2,3-B]THIOPHENEYL]AMINO]-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Springer, T.A, Zhu, J, Xiao, T. | | Deposit date: | 2007-09-18 | | Release date: | 2008-09-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
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8GCE
 | | The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Huo, T, Wu, H, Wang, Z. | | Deposit date: | 2023-03-01 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 2024
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7LA4
 | | Integrin AlphaIIbBeta3-PT25-2 Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J. | | Deposit date: | 2021-01-05 | | Release date: | 2022-01-12 | | Last modified: | 2022-07-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
Blood Adv, 5, 2021
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8T2V
 | | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | Deposit date: | 2023-06-06 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
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4CAK
 | | Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-IIb, ... | | Authors: | Choi, W.S, Rice, W.J, Stokes, D.L, Coller, B.S. | | Deposit date: | 2013-10-08 | | Release date: | 2013-10-30 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (20.5 Å) | | Cite: | Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
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1DPK
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2KNC
 | | Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | | Descriptor: | Integrin alpha-IIb, Integrin beta-3 | | Authors: | Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J. | | Deposit date: | 2009-08-20 | | Release date: | 2009-09-29 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1DPQ
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1M8O
 | | Platelet integrin alfaIIb-beta3 cytoplasmic domain | | Descriptor: | platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain | | Authors: | Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J. | | Deposit date: | 2002-07-25 | | Release date: | 2002-09-18 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A Structural mechanism of integrin alfaiib beta3
"Inside-out" Activation as regulated by its cytoplasmic face.
Cell(Cambridge,Mass.), 110, 2002
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1KUP
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1KUZ
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7SFT
 | | Filamin complex-2 | | Descriptor: | Filamin-A, Integrin alpha-IIb light chain, form 2 | | Authors: | Liu, J, Qin, J. | | Deposit date: | 2021-10-04 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage.
Blood, 141, 2023
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2K1A
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1S4W
 | | NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles | | Descriptor: | Integrin alpha-IIb | | Authors: | Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J. | | Deposit date: | 2004-01-19 | | Release date: | 2004-03-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Proc.Natl.Acad.Sci.USA, 101, 2004
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2MTP
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2N9Y
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7KN0
 | | Structure of the integrin aIIb(W968V)b3 transmembrane complex | | Descriptor: | Integrin alpha-IIb, Integrin beta-3 | | Authors: | Situ, A.J, Kim, J, An, W, Kim, C, Ulmer, T.S. | | Deposit date: | 2020-11-03 | | Release date: | 2021-09-15 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Insight Into Pathological Integrin alpha IIb beta 3 Activation From Safeguarding The Inactive State.
J.Mol.Biol., 433, 2021
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2K9J
 | | Integrin alphaIIb-beta3 transmembrane complex | | Descriptor: | Integrin alpha-IIb light chain, Integrin beta-3 | | Authors: | Lau, T, Kim, C, Ginsberg, M.H, Ulmer, T.S. | | Deposit date: | 2008-10-15 | | Release date: | 2009-03-24 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
Embo J., 28, 2009
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