2FCW
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![BU of 2fcw by Molmil](/molmil-images/mine/2fcw) | Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP). | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-2-macroglobulin receptor-associated protein, CALCIUM ION, ... | Authors: | Beglova, N, Fisher, C, Blacklow, S.C. | Deposit date: | 2005-12-12 | Release date: | 2006-05-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors Mol.Cell, 22, 2006
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3SO6
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![BU of 3so6 by Molmil](/molmil-images/mine/3so6) | |
1IJQ
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![BU of 1ijq by Molmil](/molmil-images/mine/1ijq) | Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair | Descriptor: | LOW-DENSITY LIPOPROTEIN RECEPTOR | Authors: | Jeon, H, Meng, W, Takagi, J, Eck, M.J, Springer, T.A, Blacklow, S.C. | Deposit date: | 2001-04-27 | Release date: | 2001-05-23 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat.Struct.Biol., 8, 2001
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1AJJ
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![BU of 1ajj by Molmil](/molmil-images/mine/1ajj) | LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION | Authors: | Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M. | Deposit date: | 1997-05-04 | Release date: | 1997-07-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature, 388, 1997
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5OYL
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![BU of 5oyl by Molmil](/molmil-images/mine/5oyl) | VSV G CR2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y. | Deposit date: | 2017-09-11 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun, 9, 2018
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2W2N
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![BU of 2w2n by Molmil](/molmil-images/mine/2w2n) | WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | Authors: | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | Deposit date: | 2008-11-03 | Release date: | 2008-11-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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2W2Q
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![BU of 2w2q by Molmil](/molmil-images/mine/2w2q) | PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | Authors: | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | Deposit date: | 2008-11-03 | Release date: | 2008-11-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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2W2M
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![BU of 2w2m by Molmil](/molmil-images/mine/2w2m) | WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | Authors: | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | Deposit date: | 2008-11-03 | Release date: | 2008-11-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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3BPS
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![BU of 3bps by Molmil](/molmil-images/mine/3bps) | PCSK9:EGF-A complex | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 | Authors: | Kwon, H.J. | Deposit date: | 2007-12-19 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Molecular basis for LDL receptor recognition by PCSK9. Proc.Natl.Acad.Sci.Usa, 105, 2008
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4NE9
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![BU of 4ne9 by Molmil](/molmil-images/mine/4ne9) | PCSK9 in complex with LDLR peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ... | Authors: | Liu, S. | Deposit date: | 2013-10-28 | Release date: | 2014-09-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem.Biol., 21, 2014
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2W2O
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![BU of 2w2o by Molmil](/molmil-images/mine/2w2o) | PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | Authors: | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | Deposit date: | 2008-11-03 | Release date: | 2008-11-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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2W2P
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![BU of 2w2p by Molmil](/molmil-images/mine/2w2p) | PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | Authors: | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | Deposit date: | 2008-11-03 | Release date: | 2008-11-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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3GCX
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![BU of 3gcx by Molmil](/molmil-images/mine/3gcx) | PCSK9:EGFA (pH 7.4) | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 | Authors: | McNutt, M.C, Kwon, H.J, Chen, C, Chen, J.R, Horton, J.D, Lagace, T.A. | Deposit date: | 2009-02-22 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells. J.Biol.Chem., 284, 2009
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3GCW
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![BU of 3gcw by Molmil](/molmil-images/mine/3gcw) | PCSK9:EGFA(H306Y) | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 | Authors: | Kwon, H.J. | Deposit date: | 2009-02-22 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells. J.Biol.Chem., 284, 2009
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3P5B
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![BU of 3p5b by Molmil](/molmil-images/mine/3p5b) | The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation | Descriptor: | CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 | Authors: | Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. | Deposit date: | 2010-10-08 | Release date: | 2011-10-26 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
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5OY9
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![BU of 5oy9 by Molmil](/molmil-images/mine/5oy9) | VSV G CR3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y. | Deposit date: | 2017-09-08 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun, 9, 2018
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1N7D
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![BU of 1n7d by Molmil](/molmil-images/mine/1n7d) | Extracellular domain of the LDL receptor | Descriptor: | 12-TUNGSTOPHOSPHATE, CALCIUM ION, Low-density lipoprotein receptor, ... | Authors: | Rudenko, G, Henry, L, Henderson, K, Ichtchenko, K, Brown, M.S, Goldstein, J.L, Deisenhofer, J. | Deposit date: | 2002-11-13 | Release date: | 2003-01-21 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure of the LDL receptor extracellular domain at endosomal pH Science, 298, 2002
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3P5C
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![BU of 3p5c by Molmil](/molmil-images/mine/3p5c) | The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation | Descriptor: | CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 | Authors: | Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. | Deposit date: | 2010-10-08 | Release date: | 2011-10-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
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3M0C
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1HZ8
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![BU of 1hz8 by Molmil](/molmil-images/mine/1hz8) | SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR | Descriptor: | CALCIUM ION, LOW DENSITY LIPOPROTEIN RECEPTOR | Authors: | Kurniawan, N.D, Aliabadizadeh, K, Brereton, I.M, Kroon, P.A, Smith, R. | Deposit date: | 2001-01-23 | Release date: | 2001-08-15 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor. J.Mol.Biol., 311, 2001
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1I0U
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![BU of 1i0u by Molmil](/molmil-images/mine/1i0u) | SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR | Descriptor: | CALCIUM ION, LOW DENSITY LIPOPROTEIN RECEPTOR | Authors: | Kurniawan, N.D, Aliabadizadeh, K, Brereton, I.M, Kroon, P.A, Smith, R. | Deposit date: | 2001-01-29 | Release date: | 2001-08-15 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor. J.Mol.Biol., 311, 2001
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2MG9
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![BU of 2mg9 by Molmil](/molmil-images/mine/2mg9) | Truncated EGF-A | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor | Authors: | Schroeder, C.I, Rosengren, K. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Method: | SOLUTION NMR | Cite: | Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro. Chem.Biol., 21, 2014
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2M7P
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![BU of 2m7p by Molmil](/molmil-images/mine/2m7p) | RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor, Relaxin receptor 1 | Authors: | Kong, R.CK, Petrie, E.J, Mohanty, B, Ling, J, Lee, J.C.Y, Gooley, P.R, Bathgate, R.A.D. | Deposit date: | 2013-04-29 | Release date: | 2013-08-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation. J.Biol.Chem., 288, 2013
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1XFE
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![BU of 1xfe by Molmil](/molmil-images/mine/1xfe) | Solution structure of the LA7-EGFA pair from the LDL receptor | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor | Authors: | Beglova, N, Jeon, H, Fisher, C, Blacklow, S.C. | Deposit date: | 2004-09-14 | Release date: | 2004-11-02 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Cooperation between Fixed and Low pH-Inducible Interfaces Controls Lipoprotein Release by the LDL Receptor Mol.Cell, 16, 2004
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1D2J
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![BU of 1d2j by Molmil](/molmil-images/mine/1d2j) | LDL RECEPTOR LIGAND-BINDING MODULE 6 | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR | Authors: | North, C.L, Blacklow, S.C. | Deposit date: | 1999-09-23 | Release date: | 2000-03-22 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution structure of the sixth LDL-A module of the LDL receptor. Biochemistry, 39, 2000
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