3GCX
PCSK9:EGFA (pH 7.4)
Summary for 3GCX
Entry DOI | 10.2210/pdb3gcx/pdb |
Related | 3GCW |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: Q8NBP7 Q8NBP7 Cell membrane; Single-pass type I membrane protein: P01130 |
Total number of polymer chains | 3 |
Total formula weight | 77857.85 |
Authors | McNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A. (deposition date: 2009-02-22, release date: 2009-03-03, Last modification date: 2023-09-06) |
Primary citation | McNutt, M.C.,Kwon, H.J.,Chen, C.,Chen, J.R.,Horton, J.D.,Lagace, T.A. Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells. J.Biol.Chem., 284:10561-10570, 2009 Cited by PubMed: 19224862DOI: 10.1074/jbc.M808802200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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