5OQV
| Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM | Descriptor: | Amyloid beta A4 protein | Authors: | Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. | Deposit date: | 2017-08-14 | Release date: | 2017-09-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
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8H8Q
| Fab-amyloid beta fragment complex at neutral pH | Descriptor: | CHLORIDE ION, Fab, GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY, ... | Authors: | Kita, A, Irie, K, Irie, Y, Matsushima, Y, Miki, K. | Deposit date: | 2022-10-24 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Fab-amyloid beta fragment complex at neutral pH To Be Published
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8B9Q
| Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease | Descriptor: | Amyloid-beta A4 protein, COPPER (II) ION | Authors: | Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H. | Deposit date: | 2022-10-06 | Release date: | 2023-02-08 | Last modified: | 2024-06-05 | Method: | SOLUTION NMR | Cite: | Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease. Jacs Au, 2, 2022
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7RTZ
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2BEG
| 3D Structure of Alzheimer's Abeta(1-42) fibrils | Descriptor: | Amyloid beta A4 protein | Authors: | Luhrs, T, Ritter, C, Adrian, M, Riek-Loher, D, Bohrmann, B, Dobeli, H, Schubert, D, Riek, R. | Deposit date: | 2005-10-24 | Release date: | 2005-11-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | 3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1Z0Q
| Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) | Descriptor: | Alzheimer's disease amyloid | Authors: | Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D. | Deposit date: | 2005-03-02 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding Chembiochem, 7, 2006
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3IFN
| X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex | Descriptor: | 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein | Authors: | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | Deposit date: | 2009-07-24 | Release date: | 2009-11-17 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J.Biol.Chem., 285, 2010
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5KK3
| Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils | Descriptor: | Beta-amyloid protein 42 | Authors: | Colvin, M.T, Silvers, R, Zhe Ni, Q, Can, T.V, Sergeyev, I, Rosay, M, Donovan, K.J, Michael, B, Wall, J, Linse, S, Griffin, R.G. | Deposit date: | 2016-06-20 | Release date: | 2016-07-13 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Atomic Resolution Structure of Monomorphic A beta 42 Amyloid Fibrils. J.Am.Chem.Soc., 138, 2016
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7U4P
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1NMJ
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1HZ3
| ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) | Descriptor: | A-BETA AMYLOID | Authors: | Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P. | Deposit date: | 2001-01-23 | Release date: | 2001-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J.Struct.Biol., 130, 2000
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5MYK
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8FF2
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8FF3
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7B3K
| Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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7B3J
| Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2021-12-08 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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7Q4M
| Type II beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-11-01 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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7Q4B
| Type I beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-10-30 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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5MYX
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4ONG
| Fab fragment of 3D6 in complex with amyloid beta 1-40 | Descriptor: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... | Authors: | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | Deposit date: | 2014-01-28 | Release date: | 2014-06-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab. Alzheimers Res Ther, 6, 2014
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7JXO
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7E6P
| Fab-amyloid beta fragment complex | Descriptor: | 1,2-ETHANEDIOL, Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kita, A, Irie, K, Irie, Y, Miki, K. | Deposit date: | 2021-02-23 | Release date: | 2022-01-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Characterization of a Conformation-Restricted Amyloid beta Peptide and Immunoreactivity of Its Antibody in Human AD brain. Acs Chem Neurosci, 12, 2021
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6WXM
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8EZE
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7Y8Q
| Amyloid-beta assemblage on GM1-containing membranes | Descriptor: | Amyloid-beta protein 40 | Authors: | Yagi-Utsumi, M, Itoh, S.G, Okumura, H, Yanagisawa, K, Kato, K, Nishimura, K. | Deposit date: | 2022-06-24 | Release date: | 2023-07-05 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | The Double-Layered Structure of Amyloid-beta Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization. Acs Chem Neurosci, 14, 2023
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