8VYM
| Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs | Descriptor: | 1G2 Fab Heavy Chain, 1G2 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sponholtz, M.R, Byrne, P.O, McLellan, J.S. | Deposit date: | 2024-02-09 | Release date: | 2024-09-18 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VYN
| Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model | Descriptor: | 1G2 Fab Heavy Chain, 1G2 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sponholtz, M.R, Byrne, P.O, McLellan, J.S. | Deposit date: | 2024-02-09 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation. Proc.Natl.Acad.Sci.USA, 121, 2024
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8RH1
| Trimeric HSV-2F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. | Descriptor: | Envelope glycoprotein B, HDIT101 Fab heavy chain, HDIT101 Fab light chain | Authors: | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | Deposit date: | 2023-12-14 | Release date: | 2024-06-19 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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8RH2
| Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. | Descriptor: | Envelope glycoprotein B, HDIT102 Fab heavy chain, HDIT102 Fab light chain | Authors: | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | Deposit date: | 2023-12-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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8RGZ
| Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. | Descriptor: | Envelope glycoprotein B, HDIT101 Fab heavy chain, HDIT101 Fab light chain | Authors: | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | Deposit date: | 2023-12-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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8RH0
| Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. | Descriptor: | Envelope glycoprotein B, HDIT102 Fab heavy chain | Authors: | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | Deposit date: | 2023-12-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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8KFA
| Cryo-EM structure of HSV-1 gB with D48 Fab complex | Descriptor: | D48 heavy chain, D48 light chain, Envelope glycoprotein B | Authors: | Yang, J, Sun, C, Fang, X, Zeng, M, Liu, Z. | Deposit date: | 2023-08-15 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses hlife, 2023
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7YRN
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7UI0
| Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab | Descriptor: | Envelope glycoprotein B, HSV10-13 Fab Heavy chain, HSV10-13 Light chain | Authors: | Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. | Deposit date: | 2022-03-28 | Release date: | 2023-02-08 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice. J.Clin.Invest., 133, 2023
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7UHZ
| Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab | Descriptor: | BMPC-23 Fab Heavy chain, BMPC-23 Fab Light chain, Envelope glycoprotein B | Authors: | Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. | Deposit date: | 2022-03-28 | Release date: | 2023-02-08 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice. J.Clin.Invest., 133, 2023
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7FBI
| Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 | Descriptor: | 3A3 heavy chain, 3A3 light chain, 3A5 heavy chain, ... | Authors: | Zheng, Q, Li, S, Zha, Z, Hong, J, Chen, Y, Zhang, X. | Deposit date: | 2021-07-10 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 To Be Published
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7KDP
| HCMV prefusion gB in complex with fusion inhibitor WAY-174865 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-09 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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7KDD
| HCMV postfusion gB in complex with SM5-1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-08 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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7K1S
| The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oliver, S.L. | Deposit date: | 2020-09-08 | Release date: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. Plos Pathog., 17, 2021
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6Z9M
| Pseudoatomic model of the pre-fusion conformation of glycoprotein B of Herpes simplex virus 1 | Descriptor: | Envelope glycoprotein B | Authors: | Vollmer, B, Prazak, V, Vasishtan, D, Jefferys, E.E, Hernandez-Duran, A, Vallbracht, M, Klupp, B, Mettenleiter, T.C, Backovic, M, Rey, F.A, Topf, M, Gruenewald, K. | Deposit date: | 2020-06-04 | Release date: | 2020-10-07 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | The prefusion structure of herpes simplex virus glycoprotein B. Sci Adv, 6, 2020
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6VN1
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6VLK
| A varicella-zoster virus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, ... | Authors: | Xing, Y. | Deposit date: | 2020-01-24 | Release date: | 2020-07-15 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.4529 Å) | Cite: | A glycoprotein B-neutralizing antibody structure at 2.8 angstrom uncovers a critical domain for herpesvirus fusion initiation. Nat Commun, 11, 2020
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5ZS0
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6BM8
| Crystal structure of glycoprotein B from Herpes Simplex Virus type I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, ... | Authors: | Cooper, R.S, Heldwein, E.E. | Deposit date: | 2017-11-13 | Release date: | 2018-05-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB. Nat. Struct. Mol. Biol., 25, 2018
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5YS6
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5YS2
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6ESC
| Crystal structure of Pseudorabies virus glycoprotein B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, GLYCEROL | Authors: | Backovic, M, Vaney, M.C, Rey, F.A, Haouz, A. | Deposit date: | 2017-10-20 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops. J.Virol., 92, 2018
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5V2S
| Crystal structure of glycoprotein B from Herpes Simplex Virus type I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B | Authors: | Cooper, R.S, Heldwein, E.E. | Deposit date: | 2017-03-06 | Release date: | 2018-05-16 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB. Nat. Struct. Mol. Biol., 25, 2018
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5CXF
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5C6T
| Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab | Descriptor: | 1G2 Fab heavy chain, 1G2 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chandramouli, S, Ciferri, C, Settembre, E.C, Carfi, A. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nat Commun, 6, 2015
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