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5J6E	Structure of disulfide crosslinked A. fumigatus FKBP12(V91C) Descriptor: FK506-binding protein 1A Authors: Schumacher, M. Deposit date: 2016-04-04 Release date: 2016-09-14 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
3JYM	Crystal Structure of the 3 FKBP domains of wheat FKBP73 Descriptor: FK506-binding protein (FKBP) from wheat Authors: Dym, O, Breiman, A, Israel Structural Proteomics Center (ISPC) Deposit date: 2009-09-22 Release date: 2010-06-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain J.STRUCT.FUNCT.GENOM., 11, 2010
4W9O	The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one Descriptor: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. Deposit date: 2014-08-27 Release date: 2014-12-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs). Angew.Chem.Int.Ed.Engl., 54, 2015
7R0L	Structure of the FK1 domain of the FKBP51 G64S variant in complex with SAFit1 Descriptor: 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... Authors: Meyners, C, Hausch, F. Deposit date: 2022-02-02 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Binding pocket stabilization by high-throughput screening of yeast display libraries. Front Mol Biosci, 9, 2022
4MGV	Crystal structure of FK506 binding domain of plasmodium VIVAX FKBP35 In complex with inhibitor D5 Descriptor: 70 kDa peptidylprolyl isomerase, putative, N'-(1-adamantylcarbonyl)pyridine-4-carbohydrazide Authors: Rajan, S, Harikishore, A, Yoon, H.S. Deposit date: 2013-08-29 Release date: 2013-12-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. Acs Med.Chem.Lett., 4, 2013
6VRX	Mucor circinelloides FKBP12 protein bound with FK506 in P3221 space group Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidylprolyl isomerase Authors: Gobeil, S, Spicer, L. Deposit date: 2020-02-10 Release date: 2020-12-16 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
4W9P	The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one Descriptor: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. Deposit date: 2014-08-27 Release date: 2014-12-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs). Angew.Chem.Int.Ed.Engl., 54, 2015
4W9Q	The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one Descriptor: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. Deposit date: 2014-08-27 Release date: 2014-12-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.08 Å) Cite: Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs). Angew.Chem.Int.Ed.Engl., 54, 2015
6W1N	Pig Ryanodine Receptor (WT) in 5mM EGTA condition Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ZINC ION Authors: Woll, K.W, Haji-Ghassemi, O, Van Petegem, F. Deposit date: 2020-03-04 Release date: 2021-01-06 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nat Commun, 12, 2021
4MSP	Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs Descriptor: CALCIUM ION, PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase FKBP14, ... Authors: Boudko, S.P, Ishikawa, Y, Bachinger, H.P. Deposit date: 2013-09-18 Release date: 2013-12-25 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs. Protein Sci., 23, 2014
5BXJ	Complex of the Fk1 domain mutant A19T of FKBP51 with 4-Nitrophenol Descriptor: P-NITROPHENOL, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Wu, D, Tao, X, Chen, Z, Han, J, Jia, W, Li, X, Wang, Z, He, Y.X. Deposit date: 2015-06-09 Release date: 2016-05-25 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.24 Å) Cite: The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells J. Hazard. Mater., 307, 2016
2Y78	Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei Descriptor: CHLORIDE ION, GLYCEROL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, ... Authors: Norville, I.H, O'Shea, K, Sarkar-Tyson, M, Harmer, N.J. Deposit date: 2011-01-28 Release date: 2011-05-25 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (0.91 Å) Cite: The Structure of a Burkholderia Pseudomallei Immunophilin-Inhibitor Complex Reveals New Approaches to Antimicrobial Development Biochem.J., 437, 2011
3CGN	Crystal Structure of thermophilic SlyD Descriptor: Peptidyl-prolyl cis-trans isomerase, SULFATE ION Authors: Neumann, P, Loew, C, Stubbs, M.T, Balbach, J. Deposit date: 2008-03-06 Release date: 2009-03-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus J.Mol.Biol., 398, 2010
3CGM	Crystal structure of thermophilic SlyD Descriptor: GLYCEROL, NICKEL (II) ION, Peptidyl-prolyl cis-trans isomerase, ... Authors: Loew, C, Neumann, P, Stubbs, M.T, Balbach, J. Deposit date: 2008-03-06 Release date: 2009-03-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus J.Mol.Biol., 398, 2010
5L1D	Structure of rabbit RyR2 in complex with FKBP12.6 in a closed state (conformation C1) Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor Authors: Dhindwal, S, Lobo, J.J, Samso, M. Deposit date: 2016-07-29 Release date: 2017-05-24 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (11 Å) Cite: A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor. Sci.Signal., 10, 2017
5ZR0	Solution structure of peptidyl-prolyl cis/trans isomerase domain of Trigger Factor in complex with MBP Descriptor: Maltose-binding periplasmic protein,Trigger factor Authors: Kawagoe, S, Nakagawa, H, Kumeta, H, Ishimori, K, Saio, T. Deposit date: 2018-04-21 Release date: 2018-08-22 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structural insight into prolinecis/transisomerization of unfolded proteins catalyzed by the trigger factor chaperone. J. Biol. Chem., 293, 2018
6B4P	Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri Descriptor: Peptidylprolyl Isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-09-27 Release date: 2017-10-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal Structure of Peptidylprolyl Isomerase from Naegleria fowleri to be published
3B7X	Crystal structure of human FK506-Binding Protein 6 Descriptor: FK506-binding protein 6 Authors: Walker, J.R, Davis, T, Butler-Cole, C, Paramanathan, R, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2007-10-31 Release date: 2007-11-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Human FK506-Binding Protein 6. To be Published
6PV6	Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots Descriptor: CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... Authors: Dashti, A, des Georges, A, Frank, J, Ourmazd, A. Deposit date: 2019-07-19 Release date: 2020-08-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Retrieving functional pathways of biomolecules from single-particle snapshots. Nat Commun, 11, 2020
1A7X	FKBP12-FK1012 COMPLEX Descriptor: BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER, FKBP12 Authors: Schultz, L.W, Clardy, J. Deposit date: 1998-03-18 Release date: 1998-06-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. Bioorg.Med.Chem.Lett., 8, 1998
1BKF	FK506 BINDING PROTEIN FKBP MUTANT R42K/H87V COMPLEX WITH IMMUNOSUPPRESSANT FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN Authors: Itoh, S, Decenzo, M.T, Livingston, D.J, Pearlman, D.A, Navia, M.A. Deposit date: 1995-10-18 Release date: 1996-08-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Conformation of Fk506 in X-Ray Structures of its Complexes with Human Recombinant Fkbp12 Mutants Bioorg.Med.Chem.Lett., 5, 1995
6RCY	CRYSTAL STRUCTURE OF FK1 DOMAIN OF FKBP52 IN COMPLEX WITH A BIO-INSPIRED HYBRID FLUORESCENT LIGAND Descriptor: (2~{S})-5-carbamimidamido-2-[[(2~{S})-2-[[(2~{S})-1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]carbonylamino]-4-phenyl-butanoyl]amino]pentanoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4 Authors: Li de la Sierra-Gallay, I, Byrne, C. Deposit date: 2019-04-12 Release date: 2020-05-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52. J.Med.Chem., 63, 2020
1YAT	IMPROVED CALCINEURIN INHIBITION BY YEAST FKBP12-DRUG COMPLEXES. CRYSTALLOGRAPHIC AND FUNCTIONAL ANALYSIS Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN Authors: Rotonda, J, Becker, J.W. Deposit date: 1993-01-06 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis. J.Biol.Chem., 268, 1993
6OQA	Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product Descriptor: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... Authors: Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L. Deposit date: 2019-04-26 Release date: 2020-04-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc.Natl.Acad.Sci.USA, 117, 2020
4BF8	Fpr4 PPI domain Descriptor: FPR4 Authors: Monneau, Y, Mackereth, C. Deposit date: 2013-03-15 Release date: 2013-07-31 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structure and Activity of the Peptidyl-Prolyl Isomerase Domain from the Histone Chaperone Fpr4 Towards Histone H3 Proline Isomerization J.Biol.Chem., 288, 2013

 

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