6VRX

Mucor circinelloides FKBP12 protein bound with FK506 in P3221 space group

Summary for 6VRX

Entry DOI	10.2210/pdb6vrx/pdb
Related	6VCT
Descriptor	Peptidylprolyl isomerase, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN (3 entities in total)
Functional Keywords	fk506-binding protein 1a, fkbp12, fk506, isomerase
Biological source	Mucor circinelloides
Total number of polymer chains	4
Total formula weight	51598.73
Authors	Gobeil, S.,Spicer, L. (deposition date: 2020-02-10, release date: 2020-12-16, Last modification date: 2023-10-11)
Primary citation	Gobeil, S.M.,Bobay, B.G.,Juvvadi, P.R.,Cole, D.C.,Heitman, J.,Steinbach, W.J.,Venters, R.A.,Spicer, L.D. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12:e0300021-e0300021, 2021 Cited by PubMed: 34809463 DOI: 10.1128/mBio.03000-21 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation