8HFH
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![BU of 8hfh by Molmil](/molmil-images/mine/8hfh) | CENP-E motor domain in complex with AMPPNP and Mg2+ | Descriptor: | Centromere-associated protein E, IMIDAZOLE, MAGNESIUM ION, ... | Authors: | Shibuya, A, Yokoyama, H. | Deposit date: | 2022-11-10 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue. Febs Lett., 597, 2023
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8BJS
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![BU of 8bjs by Molmil](/molmil-images/mine/8bjs) | Apo KIF20A[55-510] crystal structure | Descriptor: | Kinesin-like protein KIF20A, SULFATE ION, UNK-UNK-UNK-UNK | Authors: | Ranaivoson, F.M, Kikuti, C, Crozet, V, Sirkia, M.E, Houdusse, A. | Deposit date: | 2022-11-06 | Release date: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6. Open Biology, 13, 2023
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5W3D
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![BU of 5w3d by Molmil](/molmil-images/mine/5w3d) | The structure of kinesin-14 wild-type Ncd-ADP dimer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein claret segregational | Authors: | Park, H.W, Ma, Z, Chacko, J, Jiang, S.M, Robinson, R.C, Endow, S.A. | Deposit date: | 2017-06-07 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. Sci Rep, 7, 2017
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4FRZ
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![BU of 4frz by Molmil](/molmil-images/mine/4frz) | |
3CNZ
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![BU of 3cnz by Molmil](/molmil-images/mine/3cnz) | Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin heavy chain-like protein, MAGNESIUM ION | Authors: | Vinogradova, M.V, Malanina, G.G, Reddy, V, Reddy, A.S.N, Fletterick, R.J. | Deposit date: | 2008-03-26 | Release date: | 2008-06-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J.Struct.Biol., 163, 2008
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3T0Q
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![BU of 3t0q by Molmil](/molmil-images/mine/3t0q) | Motor Domain Structure of the Kar3-like kinesin from Ashbya gossypii | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, AGR253Wp, ... | Authors: | Duan, D, Hnatchuk, D.J, Brenner, J, Davis, D, Allingham, J.S. | Deposit date: | 2011-07-20 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of the Kar3-like kinesin motor domain from the filamentous fungus Ashbya gossypii. Proteins, 80, 2012
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4GKR
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![BU of 4gkr by Molmil](/molmil-images/mine/4gkr) | |
3DC4
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![BU of 3dc4 by Molmil](/molmil-images/mine/3dc4) | Crystal structure of the Drosophila kinesin family member NOD in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein Nod, MAGNESIUM ION | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | Deposit date: | 2008-06-03 | Release date: | 2009-02-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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3NWN
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![BU of 3nwn by Molmil](/molmil-images/mine/3nwn) | Crystal structure of the human KIF9 motor domain in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Kinesin-like protein KIF9, ... | Authors: | Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-09 | Release date: | 2010-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the human KIF9 motor domain in complex with ADP To be Published
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1X88
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![BU of 1x88 by Molmil](/molmil-images/mine/1x88) | Human Eg5 motor domain bound to Mg-ADP and monastrol | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | Authors: | Maliga, Z, Mitchison, T.J. | Deposit date: | 2004-08-17 | Release date: | 2005-11-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis of Eg5 Inhibition by Monastrol TO BE PUBLISHED
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7EOB
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![BU of 7eob by Molmil](/molmil-images/mine/7eob) | Crystal structure of KIF1A Motor-Neck domain E239K mutant with ADP-Mg-AlFx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF1A, ... | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | Deposit date: | 2021-04-21 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle. Embo J., 41, 2022
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7EO9
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![BU of 7eo9 by Molmil](/molmil-images/mine/7eo9) | Crystal structure of KIF1A Motor-Neck domain with ADP-Mg-AlFx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF1A, ... | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | Deposit date: | 2021-04-21 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle. Embo J., 41, 2022
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7A40
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![BU of 7a40 by Molmil](/molmil-images/mine/7a40) | Nucleotide-free OSM-3 kinesin motor domain | Descriptor: | GLYCEROL, Osmotic avoidance abnormal protein 3, SULFATE ION | Authors: | Varela, F.P, Menetrey, J, Gigant, B. | Deposit date: | 2020-08-19 | Release date: | 2021-02-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism. Febs Open Bio, 11, 2021
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7A5E
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![BU of 7a5e by Molmil](/molmil-images/mine/7a5e) | OSM-3 kinesin motor domain complexed with Mg.AMPPNP | Descriptor: | GLYCEROL, MAGNESIUM ION, Osmotic avoidance abnormal protein 3, ... | Authors: | Varela, F.P, Menetrey, J, Gigant, B. | Deposit date: | 2020-08-21 | Release date: | 2021-02-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism. Febs Open Bio, 11, 2021
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1YRS
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![BU of 1yrs by Molmil](/molmil-images/mine/1yrs) | Crystal structure of KSP in complex with inhibitor 1 | Descriptor: | 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D. | Deposit date: | 2005-02-04 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP BIOORG.MED.CHEM.LETT., 15, 2005
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6G6Z
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![BU of 6g6z by Molmil](/molmil-images/mine/6g6z) | Eg5-inhibitor complex | Descriptor: | (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Talapatra, S.K, Kozielski, F, Tham, C.L. | Deposit date: | 2018-04-04 | Release date: | 2018-08-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. Eur J Med Chem, 156, 2018
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6HKY
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![BU of 6hky by Molmil](/molmil-images/mine/6hky) | Eg5-inhibitor complex | Descriptor: | (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2018-09-09 | Release date: | 2019-09-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes. Mol.Cancer Ther., 18, 2019
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6HKX
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![BU of 6hkx by Molmil](/molmil-images/mine/6hkx) | Eg5-inhibitor complex | Descriptor: | (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2018-09-09 | Release date: | 2019-09-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes. Mol.Cancer Ther., 18, 2019
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6G6Y
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![BU of 6g6y by Molmil](/molmil-images/mine/6g6y) | Eg5-inhibitor complex | Descriptor: | (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Talapatra, S.K, Kozielski, F, Tham, C.L. | Deposit date: | 2018-04-03 | Release date: | 2018-08-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. Eur J Med Chem, 156, 2018
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7RIK
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![BU of 7rik by Molmil](/molmil-images/mine/7rik) | Magic-Angle-Spinning NMR Structure of Kinesin-1 Motor Domain Assembled with Microtubules | Descriptor: | Kinesin-1 heavy chain | Authors: | Zhang, C, Guo, C, Russell, R.W, Quinn, C.M, Li, M, Williams, J.C, Gronenborn, A.M, Polenova, T. | Deposit date: | 2021-07-20 | Release date: | 2022-11-23 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation Nat Commun, 13, 2022
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1N6M
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![BU of 1n6m by Molmil](/molmil-images/mine/1n6m) | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Claret segregational protein, MAGNESIUM ION | Authors: | Yun, M, Bronner, C.E, Park, C.-G, Cha, S.-S, Park, H.-W, Endow, S.A. | Deposit date: | 2002-11-11 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd EMBO J., 22, 2003
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3PXN
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![BU of 3pxn by Molmil](/molmil-images/mine/3pxn) | Crystal structure of the Drosophila kinesin family member Kin10/NOD in complex with divalent manganese and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein Nod, MANGANESE (II) ION | Authors: | Cochran, J.C, Zhao, Y.C, Wilcox, D.E, Kull, F.J. | Deposit date: | 2010-12-10 | Release date: | 2011-12-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A metal switch for controlling the activity of molecular motor proteins. Nat.Struct.Mol.Biol., 19, 2012
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1CZ7
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![BU of 1cz7 by Molmil](/molmil-images/mine/1cz7) | THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MICROTUBULE MOTOR PROTEIN NCD | Authors: | Kozielski, F.K, De Bonis, S, Burmeister, W, Cohen-Addad, C, Wade, R. | Deposit date: | 1999-09-01 | Release date: | 1999-11-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Structure Fold.Des., 7, 1999
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1Q0B
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![BU of 1q0b by Molmil](/molmil-images/mine/1q0b) | Crystal structure of the motor protein KSP in complex with ADP and monastrol | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | Authors: | Yan, Y, Sardana, V, Xu, B, Halczenko, W, Homnick, C, Buser, C.A, Hartman, G.D, Huber, H.E, Kuo, L.C. | Deposit date: | 2003-07-15 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Inhibition of a mitotic motor protein: where, how, and conformational consequences J.Mol.Biol., 335, 2004
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4OZQ
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![BU of 4ozq by Molmil](/molmil-images/mine/4ozq) | Crystal structure of the mouse Kif14 motor domain | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Chimera of Maltose-binding periplasmic protein and Kinesin family member 14 protein | Authors: | Arora, K, Talje, L, Asenjo, A.B, Andersen, P, Atchia, K, Joshi, M, Sosa, H, Kwok, B.H, Allingham, J.S. | Deposit date: | 2014-02-18 | Release date: | 2014-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | KIF14 binds tightly to microtubules and adopts a rigor-like conformation. J.Mol.Biol., 426, 2014
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