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6IPZ	Fyn SH3 domain R96W mutant, crystallized with 18-crown-6 Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Tyrosine-protein kinase Fyn Authors: Arold, S.T, Aljedani, S.S, Shahul Hameed, U.F. Deposit date: 2018-11-05 Release date: 2018-11-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.576 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
4Y92	Crystal structure of the intertwined form of the Src tyrosine kinase SH3 domain E97T-Q128R mutant Descriptor: GLYCEROL, Protein-tyrosine kinase, SULFATE ION, ... Authors: Camara-Artigas, A, Bacarizo, J. Deposit date: 2015-02-16 Release date: 2016-03-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the intertwined form of the Src tyrosine kinase SH3 domain E97T-Q128R mutant to be published
8KDX	Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Descriptor: Microtubule-associated protein tau, Tyrosine-protein kinase Fyn Authors: Padavattan, S, Jos, S. Deposit date: 2023-08-10 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (1.01 Å) Cite: Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current. J.Mol.Biol., 436, 2024
7JT9	Fgr SH3 domain crystal structure Descriptor: Tyrosine-protein kinase Fgr Authors: Perez, I, Berndt, S, Gurevich, V.V, Iverson, T.M. Deposit date: 2020-08-17 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr. J.Mol.Biol., 434, 2022
4ZNX	Crystal structure of the Fyn-SH3 domain in complex with the high affinity peptide APP12 Descriptor: APP12, Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A. Deposit date: 2015-05-05 Release date: 2016-06-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinase. Acta Crystallogr.,Sect.F, 72, 2016
6IPY	His-tagged Fyn SH3 domain R96I mutant Descriptor: Tyrosine-protein kinase Fyn Authors: Arold, S.T, Aljedani, S.S, Shahul Hameed, U.F. Deposit date: 2018-11-05 Release date: 2018-11-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.343 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
7NET	Crystal structure of the v-Src SH3 domain W95R-I96T mutant Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, TRIETHYLENE GLYCOL, ... Authors: Camara-Artigas, A, Salinas-Garcia, M.C. Deposit date: 2021-02-04 Release date: 2021-06-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain. Acta Crystallogr D Struct Biol, 77, 2021
6NMW	Crystal structure of the human Lyn SH3 domain Descriptor: Tyrosine-protein kinase Lyn Authors: Berndt, S, Gurevich, V.V, Iverson, T.M. Deposit date: 2019-01-12 Release date: 2019-04-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.199 Å) Cite: Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase. PLoS ONE, 14, 2019
7YXW	Structure of the p22phox A200G mutant in complex with p47phox peptide Descriptor: Cytochrome b-245 light chain, Neutrophil cytosol factor 1 Authors: Cukier, C.D, Vuillard, L.M, Komjati, B, Szlavik, Z. Deposit date: 2022-02-16 Release date: 2022-03-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics Acs Med.Chem.Lett., 13, 2022
8WFF	The Crystal Structure of LYN from Biortus. Descriptor: CHLORIDE ION, CITRATE ANION, Tyrosine-protein kinase Lyn Authors: Wang, F, Cheng, W, Yuan, Z, Qi, J, Lu, Y. Deposit date: 2023-09-19 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The Crystal Structure of LYN from Biortus. To Be Published
1CSK	THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP Descriptor: C-SRC SH3 DOMAIN Authors: Mathieu, M, Wierenga, R.K. Deposit date: 1994-03-22 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. FEBS Lett., 341, 1994
1CKB	STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK Descriptor: C-CRK N-TERMINAL SH3 DOMAIN, SOS PEPTIDE (PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-ARG) Authors: Wu, X, Kuriyan, J. Deposit date: 1995-01-24 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure, 3, 1995
1CKA	STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK Descriptor: C-CRK N-TERMINAL SH3 DOMAIN, C3G PEPTIDE (PRO-PRO-PRO-ALA-LEU-PRO-PRO-LYS-LYS-ARG) Authors: Wu, X, Kuriyan, J. Deposit date: 1995-01-24 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure, 3, 1995
5IH2	Structure, thermodynamics, and the role of conformational dynamics in the interactions between the N-terminal SH3 domain of CrkII and proline-rich motifs in cAbl Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Adapter molecule crk, DI(HYDROXYETHYL)ETHER, ... Authors: Bhatt, V.S, Zeng, D, Krieger, I, Sacchettini, J.C, Cho, J.-H. Deposit date: 2016-02-28 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl. Biophys.J., 110, 2016
5IHI	Crystal Structure of the alpha spectrin SH3 domain double mutant V46G-D48G Descriptor: DI(HYDROXYETHYL)ETHER, SULFATE ION, Spectrin alpha chain, ... Authors: Camara-Artigas, A. Deposit date: 2016-02-29 Release date: 2017-03-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal Structure of the alpha spectrin SH3 domain double mutant V46G-D48G to be published
5XGG	Crystal Structure C-terminal SH3 domain of Myosin IB from Entamoeba histolytica Descriptor: SULFATE ION, Unconventional myosin IB Authors: Gautam, G, Gourinath, S. Deposit date: 2017-04-13 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal structure of the PEG-bound SH3 domain of myosin IB from Entamoeba histolytica reveals its mode of ligand recognition Acta Crystallogr D Struct Biol, 73, 2017
5XG9	Crystal Structure of PEG-bound SH3 domain of Myosin IB from Entamoeba histolytica Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, PENTAETHYLENE GLYCOL, ... Authors: Gautam, G, Gourinath, S. Deposit date: 2017-04-13 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal structure of the PEG-bound SH3 domain of myosin IB from Entamoeba histolytica reveals its mode of ligand recognition Acta Crystallogr D Struct Biol, 73, 2017
5L23	Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand Descriptor: Adapter molecule crk, C3G derived peptide, DI(HYDROXYETHYL)ETHER Authors: Bhatt, V.S, Krieger, I, Sacchettini, J, Cho, J.-H. Deposit date: 2016-07-30 Release date: 2016-09-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand To Be Published
5ZAU	Complex of the human FYN SH3 and monobody binder Descriptor: Monobody Binder, Tyrosine-protein kinase Fyn Authors: Reddy, P.P, Gulyani, A, Das, R. Deposit date: 2018-02-09 Release date: 2019-09-11 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells. Elife, 9, 2020
6A9C	Crystal Structure c-terminal SH3 domain of Myosin IB from Entamoeba histolytica bound to EhFP10(GEF) peptide. Descriptor: Peptide from Rho guanine nucleotide exchange factor, SULFATE ION, Unconventional myosin IB Authors: Gautam, G, Gourinath, S. Deposit date: 2018-07-13 Release date: 2019-06-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica. Plos Pathog., 15, 2019
7TPB	p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain Descriptor: Ras GTPase-activating protein 1, Rho GTPase-activating protein 7 Authors: Stiegler, A.L, Boggon, T.J, Chau, J.E, Vish, K.J. Deposit date: 2022-01-25 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP. Nat Commun, 13, 2022
8CF4	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the combined correction method with PDB 2NUZ Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-02 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
8CHH	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the correction method for spin-diffusion with PDB 2NUZ as reference Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-08 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
8CHG	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the correction for dipolar truncation with PDB 2NUZ Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-08 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
6RO9	Human spectrin SH3 domain D48G, E7V, K60V Descriptor: Spectrin alpha, non-erythrocytic 1 Authors: Reverter, D, Navarro, S, Ventura, S. Deposit date: 2019-05-10 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.814 Å) Cite: Human spectrin SH3 domain D48G, E7V, K60V To Be Published

 

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