PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

---

6KC4	Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD) Descriptor: Tyrosine-protein kinase Fer, phosphopeptide (EDpYENVD) Authors: Matsuura, Y. Deposit date: 2019-06-27 Release date: 2019-09-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.37 Å) Cite: High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase. Protein Sci., 28, 2019
1MIL	TRANSFORMING PROTEIN Descriptor: SHC ADAPTOR PROTEIN Authors: Mikol, V. Deposit date: 1995-09-20 Release date: 1996-11-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data. J.Mol.Biol., 254, 1995
2GE9	Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase Descriptor: Tyrosine-protein kinase BTK Authors: Cheng, J.-W, Huang, K.-C. Deposit date: 2006-03-18 Release date: 2006-10-24 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase J.Biomol.Nmr, 36, 2006
5VKO	SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
7CIO	Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha Authors: Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. Deposit date: 2020-07-08 Release date: 2020-12-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
5VKL	SPT6 tSH2-RPB1 1476-1500 pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-10-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.198 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution Descriptor: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-11-22 Release date: 2011-12-28 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
2YU7	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A Authors: Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-05 Release date: 2008-04-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
3HCK	NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures Descriptor: HCK SH2 Authors: Zhang, W, Smithgall, T.E, Gmeiner, W.H. Deposit date: 1997-03-31 Release date: 1997-10-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. FEBS Lett., 406, 1997
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-23 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4U17	Swapped dimer of the human Fyn-SH2 domain Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-15 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Swapped dimer of the human Fyn-SH2 domain To Be Published
4TZI	Structure of unliganded Lyn SH2 domain Descriptor: Tyrosine-protein kinase Lyn Authors: Wybenga-Groot, L.E. Deposit date: 2014-07-10 Release date: 2015-01-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
5D0J	Grb7 SH2 with inhibitor peptide Descriptor: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION Authors: Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. Deposit date: 2015-08-03 Release date: 2016-06-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5DF6	Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide Descriptor: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip Authors: Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2015-08-26 Release date: 2015-09-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
6R5G	C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 Descriptor: ITSM, Tyrosine-protein phosphatase non-receptor type 11 Authors: Marasco, M. Deposit date: 2019-03-25 Release date: 2020-02-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6ROY	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6SM5	MbC/SHP1-C-SH2 complex Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 Authors: Mann, G, Hantschel, O. Deposit date: 2019-08-21 Release date: 2021-01-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: MbC/SHP1-C-SH2 complex To Be Published
6PXC	N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide Descriptor: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP Authors: Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. Deposit date: 2019-07-25 Release date: 2019-12-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6PXB	N-Terminal SH2 domain of the p120RasGAP Descriptor: Ras GTPase-activating protein 1 Authors: Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. Deposit date: 2019-07-25 Release date: 2019-12-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.747 Å) Cite: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6ROZ	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
3EAC	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. Descriptor: Tyrosine-protein kinase CSK Authors: Liu, D, Seidel, R.D, Cowburn, D. Deposit date: 2008-08-25 Release date: 2009-11-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
2YSX	Solution structure of the human SHIP SH2 domain Descriptor: Signaling inositol polyphosphate phosphatase SHIP II Authors: Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-04 Release date: 2008-04-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the human SHIP SH2 domain To be Published
6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide Descriptor: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-30 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8I	Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine Descriptor: LeSH (Llo2327), O-PHOSPHOTYROSINE Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-29 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide Descriptor: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-30 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018

 

12345678910111213141516>