9LSN
 
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[3,2-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | | Authors: | Yao, Y.Q, Ma, J.B. | | Deposit date: | 2025-02-04 | | Release date: | 2026-02-11 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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9LSO
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | (4S)-4-amino-5-hydroxypentanamide, Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[3,4-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | | Authors: | Yao, Y.Q, Ma, J.B. | | Deposit date: | 2025-02-04 | | Release date: | 2026-02-11 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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9LMZ
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | (4S)-4-amino-5-hydroxypentanamide, Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | | Authors: | Yao, Y.Q, Ma, J.B. | | Deposit date: | 2025-01-20 | | Release date: | 2026-01-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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9VLE
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | 2-[4-[2-[[1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-2,4-bis(oxidanylidene)pyrimidin-5-yl]amino]-2-oxidanylidene-ethyl]phenyl]ethanoic acid, Protein argonaute-2, SULFATE ION | | Authors: | Yao, Y, Ma, J. | | Deposit date: | 2025-06-25 | | Release date: | 2026-07-01 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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9VLC
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | 3-[3-[1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-2,4-bis(oxidanylidene)pyrimidin-5-yl]phenyl]propanoic acid, Protein argonaute-2 | | Authors: | Yao, Y.Q, Ma, J.B. | | Deposit date: | 2025-06-25 | | Release date: | 2026-07-01 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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9VLD
 | | hAGO2-MID in complex with a chemical modified uridine monophosphate | | Descriptor: | 3-[4-[1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-2,4-bis(oxidanylidene)pyrimidin-5-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 | | Authors: | Yao, Y.Q, Ma, J.B. | | Deposit date: | 2025-06-25 | | Release date: | 2026-07-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | hAGO2-MID in complex with a chemical modified uridine monophosphate
To Be Published
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3LUD
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3LUK
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9BF2
 | | MID domain of Ago2 bound to UMP | | Descriptor: | Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2024-04-16 | | Release date: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
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3LUH
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3LUG
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3LUJ
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3LUC
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3QX9
 | | Crystal structure of MID domain from hAGO2 in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Protein argonaute-2 | | Authors: | Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B. | | Deposit date: | 2011-03-01 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
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3QX8
 | | Crystal structure of MID domain from hAGO2 in complex with m7GpppG | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Protein argonaute-2 | | Authors: | Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B. | | Deposit date: | 2011-03-01 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
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10BE
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9YMA
 | | Structure of AGO2 vise-RISC | | Descriptor: | Protein argonaute-2, RNA (5'-R(P*AP*CP*CP*UP*GP*CP*AP*CP*UP*AP*UP*AP*AP*GP*CP*AP*CP*UP*UP*U)-3'), RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*UP*AP*GP*UP*GP*CP*AP*GP*GP*UP*A)-3') | | Authors: | Zhang, H, Adhav, V.A, Kehling, A.C, Nakanishi, K. | | Deposit date: | 2025-10-09 | | Release date: | 2026-06-03 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | Structure of AGO2 vise-RISC
To Be Published
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9YMB
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9YM9
 | | Structure of AGO2 primary RISC (pri-RISC) | | Descriptor: | Protein argonaute-2, RNA (5'-R(P*AP*CP*CP*UP*GP*CP*AP*CP*UP*AP*UP*AP*AP*GP*CP*AP*CP*U)-3'), RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*UP*AP*GP*UP*GP*CP*AP*GP*GP*UP*AP*G)-3') | | Authors: | Zhang, H, Adhav, V.A, Kehling, A.C, Nakanishi, K. | | Deposit date: | 2025-10-09 | | Release date: | 2026-06-03 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structure of AGO2 primary RISC (pri-RISC)
To Be Published
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9YMC
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9YMD
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7D7U
 | | Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate | | Descriptor: | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2 | | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | | Deposit date: | 2020-10-06 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 27, 2021
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7C6B
 | | Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate | | Descriptor: | 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 | | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | | Deposit date: | 2020-05-21 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 27, 2021
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8D6J
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8D71
 | | Human Ago2 bound to miR122(21nt) | | Descriptor: | MAGNESIUM ION, Protein argonaute-2, miR-122-21nt | | Authors: | Xiao, Y, MacRae, I. | | Deposit date: | 2022-06-07 | | Release date: | 2023-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
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