3KLO
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![BU of 3klo by Molmil](/molmil-images/mine/3klo) | Vibrio cholerae VpsT bound to c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), D(-)-TARTARIC ACID, Transcriptional regulator VpsT | Authors: | Krasteva, P.V, Navarro, V.A.S, Sondermann, H. | Deposit date: | 2009-11-08 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science, 327, 2010
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3Q3S
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2VG6
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![BU of 2vg6 by Molmil](/molmil-images/mine/2vg6) | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | Descriptor: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-bromophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | Authors: | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | Deposit date: | 2007-11-08 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors. Biochem.Biophys.Res.Commun., 365, 2008
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2VG5
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![BU of 2vg5 by Molmil](/molmil-images/mine/2vg5) | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | Descriptor: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-chlorophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | Authors: | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | Deposit date: | 2007-11-08 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors. Biochem.Biophys.Res.Commun., 365, 2008
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4GQB
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![BU of 4gqb by Molmil](/molmil-images/mine/4gqb) | Crystal Structure of the human PRMT5:MEP50 Complex | Descriptor: | (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ... | Authors: | Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S. | Deposit date: | 2012-08-22 | Release date: | 2012-10-17 | Last modified: | 2018-11-21 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal structure of the human PRMT5:MEP50 complex. Proc.Natl.Acad.Sci.USA, 109, 2012
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3EET
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![BU of 3eet by Molmil](/molmil-images/mine/3eet) | Crystal structure of putative GntR-family transcriptional regulator | Descriptor: | Putative GntR-family transcriptional regulator | Authors: | Chang, C, Xu, X, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-09-05 | Release date: | 2008-09-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.969 Å) | Cite: | Crystal structure of putative GntR-family transcriptional regulator from Streptomyces avermitilis To be Published
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2VKE
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2VG7
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![BU of 2vg7 by Molmil](/molmil-images/mine/2vg7) | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | Descriptor: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-iodophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | Authors: | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | Deposit date: | 2007-11-08 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors. Biochem.Biophys.Res.Commun., 365, 2008
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3EDP
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![BU of 3edp by Molmil](/molmil-images/mine/3edp) | |
8XT1
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![BU of 8xt1 by Molmil](/molmil-images/mine/8xt1) | Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline | Descriptor: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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1YGS
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![BU of 1ygs by Molmil](/molmil-images/mine/1ygs) | CRYSTAL STRUCTURE OF THE SMAD4 TUMOR SUPPRESSOR C-TERMINAL DOMAIN | Descriptor: | SMAD4 | Authors: | Shi, Y, Hata, A, Lo, R.S, Massague, J, Pavletich, N.P. | Deposit date: | 1997-10-03 | Release date: | 1998-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature, 388, 1997
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1Y28
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![BU of 1y28 by Molmil](/molmil-images/mine/1y28) | Crystal structure of the R220A metBJFIXL HEME domain | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Sensor protein fixL | Authors: | Dunham, C.M, Dioum, E.M, Tuckerman, J.R, Gonzalez, G, Scott, W.G, Gilles-Gonzalez, M.A. | Deposit date: | 2004-11-21 | Release date: | 2004-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A distal arginine in the oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure Biochemistry, 42, 2003
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8XT3
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![BU of 8xt3 by Molmil](/molmil-images/mine/8xt3) | Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline | Descriptor: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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1YCQ
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1YDG
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![BU of 1ydg by Molmil](/molmil-images/mine/1ydg) | |
8XT0
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![BU of 8xt0 by Molmil](/molmil-images/mine/8xt0) | Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline | Descriptor: | 12s rRNA, 16s rRNA, 39S ribosomal protein L22, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8XT2
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![BU of 8xt2 by Molmil](/molmil-images/mine/8xt2) | Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline | Descriptor: | 12s rRNA, 16s rRNA, 39S ribosomal protein L22, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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6T3L
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![BU of 6t3l by Molmil](/molmil-images/mine/6t3l) | PAS-GAF fragment from Deinococcus radiodurans phytochrome in dark state | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | Authors: | Claesson, E, Takala, H, Yuan Wahlgren, W, Pandey, S, Schmidt, M, Westenhoff, S. | Deposit date: | 2019-10-11 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser. Elife, 9, 2020
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6T3U
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![BU of 6t3u by Molmil](/molmil-images/mine/6t3u) | PAS-GAF fragment from Deinococcus radiodurans phytochrome 1ps after photoexcitation | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | Authors: | Claesson, E, Takala, H, Yuan Wahlgren, W, Pandey, S, Schmidt, M, Westenhoff, S. | Deposit date: | 2019-10-11 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser. Elife, 9, 2020
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8WQ3
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![BU of 8wq3 by Molmil](/molmil-images/mine/8wq3) | Crystal structure of the C-terminal RRM domain of an RBP | Descriptor: | CHLORIDE ION, RNA-binding protein 45 | Authors: | Chen, X, Jiang, M, Yang, Z, Chen, X, Wei, Q, Guo, S, Wang, M. | Deposit date: | 2023-10-10 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural basis for RNA recognition by the C-terminal RRM domain of human RBM45. J.Biol.Chem., 2024
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1Y5R
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![BU of 1y5r by Molmil](/molmil-images/mine/1y5r) | The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone | Descriptor: | CORTICOSTERONE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ... | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S. | Deposit date: | 2004-12-02 | Release date: | 2005-05-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes Biochemistry, 44, 2005
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6T2C
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![BU of 6t2c by Molmil](/molmil-images/mine/6t2c) | Bat Influenza A polymerase recycling complex | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-08 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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1Y7Q
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![BU of 1y7q by Molmil](/molmil-images/mine/1y7q) | Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain | Descriptor: | Zinc finger protein 174 | Authors: | Ivanov, D, Stone, J.R, Maki, J.L, Collins, T, Wagner, G. | Deposit date: | 2004-12-09 | Release date: | 2005-01-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mammalian SCAN Domain Dimer Is a Domain-Swapped Homolog of the HIV Capsid C-Terminal Domain Mol.Cell, 17, 2005
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4UY1
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![BU of 4uy1 by Molmil](/molmil-images/mine/4uy1) | Novel pyrazole series of group X Secretory Phospholipase A2 (sPLA2-X) inhibitors | Descriptor: | 5-(2,5-DIMETHYL-3-THIENYL)-1H-PYRAZOLE-3-CARBOXAMIDE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sandmark, J, Oster, L, Hallberg, K, Bodin, C, Chen, H. | Deposit date: | 2014-08-28 | Release date: | 2014-10-15 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a Novel Pyrazole Series of Group X Secreted Phospholipase A2 Inhibitor (Spla2X) Via Fragment Based Virtual Screening Bioorg.Med.Chem.Lett., 24, 2014
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1Y5M
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![BU of 1y5m by Molmil](/molmil-images/mine/1y5m) | The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes | Descriptor: | Corticosteroid 11-beta-dehydrogenase, isozyme 1, N-OCTANE, ... | Authors: | Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.R. | Deposit date: | 2004-12-02 | Release date: | 2005-05-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes Biochemistry, 44, 2005
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