4UY1

Novel pyrazole series of group X Secretory Phospholipase A2 (sPLA2-X) inhibitors

Summary for 4UY1

Entry DOI	10.2210/pdb4uy1/pdb
Descriptor	GROUP 10 SECRETORY PHOSPHOLIPASE A2, CALCIUM ION, PENTAETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	hydrolase, fragment based lead generation, virtual screening, drug discovery
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted : O15496
Total number of polymer chains	2
Total formula weight	31274.07
Authors	Sandmark, J.,Oster, L.,Hallberg, K.,Bodin, C.,Chen, H. (deposition date: 2014-08-28, release date: 2014-10-15, Last modification date: 2018-04-04)
Primary citation	Chen, H.,Knerr, L.,Akerud, T.,Hallberg, K.,Bodin, C.,Oster, L.,Rohman, M.,Osterlund, K.,Beisel, H.G.,Olsson, T.,Brengdhal, J.,Sandmark, J. Discovery of a Novel Pyrazole Series of Group X Secreted Phospholipase A2 Inhibitor (Spla2X) Via Fragment Based Virtual Screening Bioorg.Med.Chem.Lett., 24:5251-, 2014 Cited by PubMed: 25316315 DOI: 10.1016/J.BMCL.2014.09.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation